| TRPC6与肾脏疾病关系的研究进展 |
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| 引用本文： | 曹珊,刘运广.TRPC6与肾脏疾病关系的研究进展[J].中国当代儿科杂志,2018,20(1):72-76. |
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| 作者姓名： | 曹珊 刘运广 |
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| 作者单位： | 曹珊;1., 刘运广;2. |
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| 基金项目： | 国家自然科学基金项目（81460143）。 |
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| 摘 要： | 瞬时受体电位阳离子通道蛋白6（TRPC6）是由TRPC6基因编码的瞬时受体超家族成员之一，在人体内各组织或器官广泛表达，在肾小球足细胞也有表达。TRPC6与podocin、nephrin、ACTN4及CD2AP等多种裂孔隔膜（SD）蛋白相互作用共同维系肾小球足细胞的结构及功能。多因素作用导致肾小球足细胞损伤引起SD的足突融合是肾脏疾病最主要的形态学改变。该文就TRPC6生物学功能及其对肾脏疾病的影响作一简述。
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| 关 键 词： | TRPC6 肾小球足细胞 肾脏疾病 |
| 收稿时间： | 2017/10/27 0:00:00 |
| 修稿时间： | 2017/12/11 0:00:00 |
Research advances in the association between transient receptor potential cation channel 6 and kidney disease |
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| CAO Shan,LIU Yun-Guang.Research advances in the association between transient receptor potential cation channel 6 and kidney disease[J].Chinese Journal of Contemporary Pediatrics,2018,20(1):72-76. |
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| Authors: | CAO Shan LIU Yun-Guang |
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| Institution: | CAO Shan;1., LIU Yun-Guang;2. |
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| Abstract: | Transient receptor potential cation channel 6 (TRPC6) is a member of the transient receptor superfamily encoded by the TRPC6 gene and is widely expressed in tissues and organs of the human body, especially in the glomerular podocytes. TRPC6 interacts with various slit diaphragm (SD) proteins including podocin, nephrin, ACTN4, and CD2AP to maintain the normal structure and function of glomerular podocytes. Foot process fusion caused by podocyte damage due to various factors is the most important morphological change in kidney disease. This article reviews the biological function of TRPC6 and its effect on kidney disease. |
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| Keywords: | Transient receptor potential cation channel 6|Podocyte|Kidney disease |
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