以恩丹西酮为主的联合方案预防化疗所致呕吐的临床观察

[目的]观察恩丹西酮＋甲氧氯普胺＋苯海拉明＋地塞米松预防化疗引起的恶心呕吐的临床疗效和毒副反应。[方法]对60例患者采用随机自身对照试验法，分别用恩丹西酮单药及恩丹西酮＋甲氧氯普胺＋苯海拉明＋地塞米松联合方案预防呕吐。[结果]恩丹西酮＋甲氧氯普胺＋苯海拉明＋地塞米松3天内预防呕吐的有效率分别为93.3％、95．0％、96．7％，明显优于对照组的75．0％、78．3％和75．0％（P〈0．05）。毒副作用可以耐受。[结论]恩丹西酮＋甲氧氯普胺＋苯海拉明＋地塞米松联合方案预防化疗引起的呕吐效果明显优于思丹西酮单药。

Ondansetron Based Combination Regimen for Prophylaxis of Chemotherapy Induced Emesis

[Purposel To investigate clinical efficacy and toxieity of ondansetron based combination regimen （ondansetron＋metoehopramide＋diphenhydramine＋dexamethasone） in prevention of nausea and vomiting induced by chemotherapy. [Methods] In this randomized, self-cross control study, 60 patients were observed. Before chemotherapy, patients received ondansetron alone or ondansetron plus metoehopramide, diphenhydramine and dexamethasone to prevent nausea and vomiting induced by chemotherapy. [Resultl The response rates of emesis prevention of day 1-3 in combination regimen group were 93.3%, 95.0%, 96.7%, and 75.0%, 78.3%, 75.0% respectively in ondansetron alone group. The response rates were significantly higher in combination regimen group than those in ondansetron alone group （P〈0.05）. Toxieities were tolerable. [Conclusion] Ondansetron based combination regimen is superior to ondansetron alone in prevention emesis induced by chemotherapy.