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Platelet [3H]imipramine binding in psychiatric disorders

Authors:	P D Kanof E F Coccaro C A Johns L J Siever K L Davis

Institution:	1. Allergan plc, Madison, NJ, USA;2. George Washington University/Bracket Global, LLC, Washington, DC, USA;3. Saint Louis University, St. Louis, MO, USA;4. Gedeon Richter Plc, Budapest, Hungary;1. Allergan, Inc., Jersey City, NJ, USA;2. Gedeon Richter Plc, Budapest, Hungary;3. Department of Psychiatry, Psychotherapy and Psychosomatics, Medical University Innsbruck, Innsbruck, Austria;4. Saint Louis University, St. Louis, MO, USA;1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum rechts der Isar, Technische Universität München, München, Germany;2. Medical Division, Gedeon Richter Plc., Budapest, Hungary;3. School of Public Health, University of Haifa, Israel

Abstract:	The Bmax and Kd values for 3H]imipramine binding were measured in platelets from drug-free normal controls and schizophrenic and depressive patients. No differences among groups were found. Exacerbated and remitted patients with either schizophrenia or depression did not differ in platelet 3H]imipramine binding parameters. No correlations were observed between platelet 3H]imipramine binding parameters and measures of symptom severity among actively ill patients with either schizophrenia or depression.

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