| 桑黄多糖对肥大细胞脱颗粒的机制 |
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| 引用本文： | 洪海,金光日,金光玉,延光海. 桑黄多糖对肥大细胞脱颗粒的机制[J]. 中国医院药学杂志, 2011, 0(18) |
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| 作者姓名： | 洪海 金光日 金光玉 延光海 |
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| 作者单位： | 延边中医医院药剂科;延边大学附属医院药剂科;延边大学医学部解剖学教研部; |
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| 基金项目： | 国家自然基金(编号:81060003); 吉林省教育厅项目[(2009)第28号] |
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| 摘 要： | 目的:观察桑黄多糖的抗过敏作用并探讨其可能的作用机制。方法:通过IgE诱导大鼠被动皮肤过敏反应(PCA)实验,用比色法测定桑黄多糖在体内对肥大细胞影响。体外实验观察桑黄多糖对IgE诱导组胺释放、细胞内钙摄入及其他炎性介子的影响。结果:桑黄多糖明显抑制了肥大细胞脱颗粒、组胺的释放、细胞内钙摄入以及肿瘤坏死因子-α、白细胞介素6的释放(P<0.05)。结论:桑黄多糖抗过敏作用与抑制肥大细胞脱颗粒及炎性介子的释放有关。
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| 关 键 词： | 肥大细胞 桑黄多糖 免疫球蛋白E 组胺 钙 |
Effect of polysaccharides from Phellinus linteus on degranulation of mast cell |
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| HONG Hai,JIN Guang-ri,JIN Guang-yu,YAN Guang-hai. Effect of polysaccharides from Phellinus linteus on degranulation of mast cell[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(18) |
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| Authors: | HONG Hai JIN Guang-ri JIN Guang-yu YAN Guang-hai |
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| Affiliation: | HONG Hai1,JIN Guang-ri2,JIN Guang-yu2,YAN Guang-hai3 (1.Yanbian Chinese medicine hospital,Jilin Yanji 133000,China,2.Department of pharmacy,Yanbian University Hospital Jilin Yanji 133000,3.Department of Anatomy Yanbian University Jilin Yanji 133000,China) |
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| Abstract: | OBJECTIVE To investigate the anti-allergic effects of polysaccharides from Phellinus linteus(PPL) and to explore its possible mechanism. METHODS The experiment of passive cutaneous anaphylaxis was used to determine the effect of PPL on degranulation of mast cells in vivo.For in vitro study,various doses of PPL were added to of sensitized rat peritoneal mast cells(RPMC).The IgE-induced release of degranulation was measured by enzymatic assay,histamine by EIA and cytokines by ELISA. RESULTS Treatment with PPL... |
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| Keywords: | mast cell polysaccharides extracted from Phellinus linteus IgE histmaine calcium |
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