| 雷洛昔芬对放疗去势大鼠骨丢失的保护作用 |
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| 引用本文： | 陈静,朱芳,李贵玲.雷洛昔芬对放疗去势大鼠骨丢失的保护作用[J].中国医院药学杂志,2011(20). |
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| 作者姓名： | 陈静 朱芳 李贵玲 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院肿瘤中心; |
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| 基金项目： | 湖北省科技攻关项目(编号:2006AA301B56-7) |
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| 摘 要： | 目的:观察雷洛昔芬(选择性雌激素受体调节剂)对放疗去势大鼠的骨代谢生化指标、骨密度及骨形态学的影响,探讨其对放疗所致卵巢早衰引起骨丢失的保护作用。方法:选用3月龄雌性Wistar大鼠40只,随机分为4组:假放疗组、放疗组、放疗+雷洛昔芬组、放疗+己烯雌酚组,每组10只,16周后,腹主动脉取血,检测血清雌二醇、卵泡刺激素、骨钙素及碱性磷酸酶的水平;处死大鼠,取大鼠右侧股骨,测定各组骨密度;同时取左侧股骨制作骨切片行HE染色,观察骨形态学变化。结果:放疗组及放疗+雷洛昔芬组的雌二醇水平明显低于假放疗组及放疗+己烯雌酚组(P<0.05);而两组的卵泡刺激素水平明显高于假放疗组及放疗+己烯雌酚组(P<0.05);放疗组骨钙素和碱性磷酸酶明显高于其他3组,而另3组无明显差异(P>0.05);放疗组大鼠骨密度显著低于其他3组,其骨小梁稀疏,部分断裂,而另3组骨小梁致密,无明显断裂。结论:大鼠卵巢放疗可致去势,放疗去势后大鼠有骨质丢失发生,而选择性雌激素受体调节剂雷洛昔芬对放疗去势后大鼠的骨丢失有保护作用。
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| 关 键 词： | 雷洛昔芬 放疗 去势 骨代谢 骨密度 |
Protective effect of raloxifene in preventing bone loss in rats following radiotherapy induced gonadectomy |
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| CHEN Jing,ZHU Fang,LI Gui-ling.Protective effect of raloxifene in preventing bone loss in rats following radiotherapy induced gonadectomy[J].Chinese Journal of Hospital Pharmacy,2011(20). |
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| Authors: | CHEN Jing ZHU Fang LI Gui-ling |
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| Institution: | CHEN Jing,ZHU Fang,LI Gui-ling(Cancer center,Union hospital of Tongji Medical College,Huazhong University of Science and Techology,Hubei Wuhan 430022,China) |
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| Abstract: | OBJECTIVE To investigate the protective effect of the selective estrogen receptor modulators(SERMs) raloxifene in preventing bone loss secondary to radiotherapy induced premature ovarian failure(POF).This was studied by observing the effects of Raloxifene on biochemical markers of bone metabolism,bone morphology and bone mineral density of rats following radiotherapy induced gonadectomy.METHODS 40 female Wistar rats aged 3 months were randomly divided into 4 groups(10 rats in each group): Group A(sham radio... |
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| Keywords: | raloxifene radiotherapy gonadectomy bone metabolism bone mineral density |
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