| 一种聚乳酸聚乙醇酸缓释微球的制备工艺 |
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| 引用本文： | 罗宇燕,张永明,吴传斌.一种聚乳酸聚乙醇酸缓释微球的制备工艺[J].中国医院药学杂志,2011(11). |
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| 作者姓名： | 罗宇燕 张永明 吴传斌 |
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| 作者单位： | 中山大学药学院;中山大学附属第三医院; |
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| 基金项目： | 广东省科技计划资助项目(编号:2008B030301339) |
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| 摘 要： | 目的:研究一种制备聚乳酸聚乙醇酸(PLGA)微球的新工艺,即将海藻酸钠与钙离子螯合形成缓释凝胶的原理与复乳法制备微球的工艺相结合。方法:以牛血清白蛋白(BSA)为模型药,以包封率、载药量、产率作为评价指标,研究PLGA黏度、海藻酸钠浓度及外水相1中氯化钙浓度对微球性质的影响,并通过L9(34)正交试验设计优选微球制备的工艺条件。结果:优选的制备工艺重现性好,微球形态圆整,结构致密,平均粒径为67.5μm,载药量、包封率和产率分别为0.669%、53.38%和80.08%。结论:本研究获得了较为满意的制备PLGA微球的新工艺,微球的理化性质良好。
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| 关 键 词： | 缓释微球 复乳法 海藻酸钠 聚乳酸聚乙醇酸微球 |
A method to prepare PLGA sustained-release microspheres |
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| LUO Yu-yan,ZHANG Yong-ming,WU Chuan-bin.A method to prepare PLGA sustained-release microspheres[J].Chinese Journal of Hospital Pharmacy,2011(11). |
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| Authors: | LUO Yu-yan ZHANG Yong-ming WU Chuan-bin |
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| Institution: | LUO Yu-yan1,ZHANG Yong-ming2,WU Chuan-bin1(1.School of pharmaceutical Sciences,Sun Yat-sen University,Guangdong Guangzhou 510006,China,2.The Third Affiliated Hospital of Sun Yat-sen University,Guangdong Guangzhou 510630,China) |
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| Abstract: | OBJECTIVE To prepare the Poly(lactide-co-glycolide)(PLGA) microspheres with a modified double-emulsion method.Based on the normal double-emulsion method,sodium alginate was added into the internal aqueous phase with protein together;meanwhile calcium chloride was put into the external aqeuous phase.while the microspheres were forming,sodium alginate produced ionic interaction with calcium ion to form sustained-release gel.METHODS Three influential factors of bovine serum albumin(BSA) microspheres including ... |
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| Keywords: | sustained-release microspheres double-emulsion method sodium alginate PLGA |
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