| 氟尿嘧啶泡囊凝胶剂的体外透皮试验 |
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| 引用本文： | 刘慧敏,杨红,刘洵含,周天一,黄娟. 氟尿嘧啶泡囊凝胶剂的体外透皮试验[J]. 中国医院药学杂志, 2011, 0(17) |
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| 作者姓名： | 刘慧敏 杨红 刘洵含 周天一 黄娟 |
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| 作者单位： | 四川大学华西药学院;苏州大学药学院; |
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| 基金项目： | 国家自然科学基金资助项目(编号:30572262) |
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| 摘 要： | 目的:研究氟尿嘧啶泡囊凝胶剂的体外透皮扩散率及皮内滞留率。方法:建立用分光光度法测定氟尿嘧啶的方法,通过离体鼠皮透皮扩散试验,测定氟尿嘧啶泡囊凝胶的透皮扩散率及皮外残留率,并与氟尿嘧啶凝胶剂和医院制剂乳膏等作对照。结果:氟尿嘧啶泡囊凝胶剂的12 h的透皮累积扩散率仅为乳膏的10%,但皮内滞留率却增加2倍以上。结论:氟尿嘧啶泡囊凝胶剂可大大减少透过皮肤进入全身的药量,显著增加局部浓度,利于提高对皮肤病的疗效和降低全身毒性。
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| 关 键 词： | 氟尿嘧啶 泡囊凝胶剂 透皮扩散 药物皮内滞留率 |
Transdermal diffusion of fluorouracil in niosomal gels in vitro |
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| LIU Hui-min,YANG Hong,,LIU Xun-han,ZHOU Tian-yi,HUANG Juan. Transdermal diffusion of fluorouracil in niosomal gels in vitro[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(17) |
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| Authors: | LIU Hui-min YANG Hong LIU Xun-han ZHOU Tian-yi HUANG Juan |
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| Affiliation: | LIU Hui-min1,YANG Hong1,2,LIU Xun-han2,ZHOU Tian-yi2,HUANG Juan1 (1.West China School of Pharmacy,Sichuan University,Sichuan Chengdu 610041,China,2.School of Pharmacy,Soochow University,Jiangsu Suzhou 215123,China) |
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| Abstract: | OBJECTIVE To study the in vitro transdermal diffusion rate and the residue rate of Fu in niosomal gels in rat skin. METHODS The method of determination for Fu by spectrophotometry was established.The in vitro transdermal diffusion of Fu in niosomal gels through the rat skin and the residues in the skin were measured and compare in vitro with in Fu gels and hospital-based creams. RESULTS The transdermal diffusion rate of Fu in niosomal gels was only 10% of that in the creams,but the drug retention rate of Fu... |
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| Keywords: | fluorouracil(Fu) niosomal gels transdermal diffusion rate of drug retained in skin |
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