| 强骨饮治疗骨关节炎合并骨质疏松患者的临床研究 |
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| 引用本文： | 吴连国,刘康,王定,张立强,史晓林,王照腾,陈华. 强骨饮治疗骨关节炎合并骨质疏松患者的临床研究[J]. 中国中医骨伤科杂志, 2011, 0(12): 10-13 |
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| 作者姓名： | 吴连国 刘康 王定 张立强 史晓林 王照腾 陈华 |
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| 作者单位： | 浙江中医药大学附属第二医院骨科;浙江中医药大学附属富阳中医骨伤医院;温州医学院附属温岭医院;浙江中医药大学附属第三医院; |
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| 基金项目： | 浙江省教育厅高校科研计划(20071125); 国家中医药管理局“十一五”重点专科(专病)建设项目 |
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| 摘 要： | 目的：观察、评价强骨饮治疗骨关节炎合并骨质疏松症患者的临床疗效及安全性，并初步探讨其作用机制。方法：将符合入选标准的患者随机分为强骨饮组及对照组塞来昔布组和仙灵骨葆组，每组各30例。观察方法：治疗组服用强骨饮每天1付，分早晚2次服用，塞来昔布组每日服塞来昔布胶囊2次，1次1粒，200mg。仙灵骨葆组服用仙灵骨葆胶囊每天2次，1次3粒，1．5g。3组均治疗2个月，疗程结束后，进行，1缶床症状评估值，测定关节滑液IL-6、TNF-α值和骨密度值。结果：强骨饮组总有效率为90．00％、塞来昔布组总有效率为76．67％、仙灵骨葆组总有效率为83．33％。强骨饮组关节滑液IL-6、TNF—α值下降最明显，与服药前相比差异有统计学意义（P〈0．01），仙灵骨葆组的IL-6、TNF—α值下降明显，与服药前比较差异有统计学意义（P〈0．05）；2组比较差异有统计学意义（P〈0．05）；塞来昔布组服药前后关节滑液IL-6、TNF—α值比较差异无统计学意义（P〉0．05）。强骨饮组和仙灵骨葆组服药前骨密度明显增加（P〈0．05），两者比较差异无统计学意义（P〉0．05），塞来昔布组服药前后骨密度比较差异无统计学意义（P〉0．05）。结论：强骨饮不但能够明显改善骨关节炎合并骨质疏松患者的临床症状和体征，而且应用该剂后关节滑液IL-6、TNF-α值明显下降，骨密度明显提高。
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| 关 键 词： | 强骨饮 骨关节炎 骨质疏松 骨密度 |
The Clinical Research of Qiangguyin for Treating Osteoarthritis Patients with Osteoporosis |
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| WU Lianguo LIU Kang WANG Ding ZHANG Liqiang SHI Xiaolin WANG Zhaoteng CHEN Hua The Second Affiliated Hospital of Zhejiang University of TCM,Hangzhou,,Zhejiang,China Fuyang Orthopaedic Hospital,Affiliated to Zhejiang University of TCM Wenling Hospital,Affiliated to Wenzhou Medical College The Third Affiliated Hospital of Zhejiang University of TCM. The Clinical Research of Qiangguyin for Treating Osteoarthritis Patients with Osteoporosis[J]. Chinese Journal of Traditional Medical Traumatology & Orthopeics, 2011, 0(12): 10-13 |
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| Authors: | WU Lianguo LIU Kang WANG Ding ZHANG Liqiang SHI Xiaolin WANG Zhaoteng CHEN Hua The Second Affiliated Hospital of Zhejiang University of TCM Hangzhou Zhejiang China Fuyang Orthopaedic Hospital Affiliated to Zhejiang University of TCM Wenling Hospital Affiliated to Wenzhou Medical College The Third Affiliated Hospital of Zhejiang University of TCM |
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| Affiliation: | WU Lianguo1 LIU Kang1 WANG Ding1 ZHANG Liqiang2 SHI Xiaolin1 WANG Zhaoteng3 CHEN Hua4 1The Second Affiliated Hospital of Zhejiang University of TCM,Hangzhou,310005,Zhejiang,China 2Fuyang Orthopaedic Hospital,Affiliated to Zhejiang University of TCM 3Wenling Hospital,Affiliated to Wenzhou Medical College 4The Third Affiliated Hospital of Zhejiang University of TCM |
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| Abstract: | Objective:To observe and evaluate the clinical efficacy and safety of the Qiangguyin on osteoarthritis patients with osteoporosis,and to explore its mechanism.Methods: All 90 cases were randomly divided into the treatment group(Qiangguyin group),the control group 1(Celecoxib group),and the control group 2(Xianlinggubao group),with 30 cases in each group.The methods of observation: the patients of treatment group were given Qiguyin one dose everyday taking in morning and evening especially;the control 1 grou... |
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| Keywords: | QiangGuYin Osteoarthritis Osteoporosis Interleukin-6 Tumor necrosis factor-alpha Bone density |
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