| 异莲心碱抗血小板聚集和抗凝血作用 |
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| 引用本文： | 陈灵骏,罗顺德.异莲心碱抗血小板聚集和抗凝血作用[J].中国医院药学杂志,2011(15). |
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| 作者姓名： | 陈灵骏 罗顺德 |
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| 作者单位： | 海口市人民医院;武汉大学人民医院; |
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| 摘 要： | 目的:探讨异莲心碱(isoliensinineI,L)对大鼠体内血小板聚集和凝血功能的影响。方法:以二磷酸腺苷(ADP)诱导血小板聚集,采用比浊法观察IL对兔体内外血小板13,5,min聚集率和最大聚集率的影响,同时评价IL对大鼠凝血酶原时间(PT)、活化部分凝血激酶时间(APTT)及凝血酶时间(TT)的影响。结果:IL 4 mg.L-1和8 mg.L-1能显著抑制ADP诱导的兔体外血小板13,5,min聚集率和最大聚集率,其抑制率为14.4%和27.9%;IL 5 mg.kg-1和10 mg.kg-1能显著抑制ADP诱导的兔体内血小板1,35,min聚集率和最大聚集率,其抑制率为20.0%和32.6%;IL能显著延长大鼠PT、APTT和TT。结论:IL具有对抗血小板聚集和凝血作用。
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| 关 键 词： | 异莲心碱 血小板聚集 凝血酶原时间 活化部分凝血激酶时间 凝血酶时间 |
Experimental study on the anti-platelet aggregation and anti-coagulant activity of isoliensinine |
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| CHEN Ling-jun,LUO Shun-de.Experimental study on the anti-platelet aggregation and anti-coagulant activity of isoliensinine[J].Chinese Journal of Hospital Pharmacy,2011(15). |
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| Authors: | CHEN Ling-jun LUO Shun-de |
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| Institution: | CHEN Ling-jun1,LUO Shun-de2(1.Department of Pharmacy,People's Hospital of Haikou,Hainan Haikou 570208,China,2.People's Hospital of Wuhan University,Hubei Wuhan 430060,China) |
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| Abstract: | OBJECTIVE To investigate the inhibitory effects of isoliensinine on platelet aggregation in rabbits and coagulation function in rats.METHODS Inhibition rates of platelet aggregation for isoliensinine in vivo and vitro were determined by the model of platelet aggregation induced by adenosine diphosphate.The effects of isoliensinine were also evaluated on prothrombin time(PT),activated partial thromboplastin time(APTT) and thrombin time(TT).RESULTS Isoliensinine inhibited platelet aggregation in vitro at the ... |
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| Keywords: | isoliensinine platelet aggregation prothrombin time activated partial thromboplastin time thrombin time |
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