| 黄芩苷滴丸成型工艺考察 |
| |
| 引用本文： | 王玉秀,贾金萍,陈大为,秦雪梅,王玉璧. 黄芩苷滴丸成型工艺考察[J]. 中国医院药学杂志, 2011, 0(10) |
| |
| 作者姓名： | 王玉秀 贾金萍 陈大为 秦雪梅 王玉璧 |
| |
| 作者单位： | 山西生物应用职业技术学院;山西大学中医药现代研究中心;沈阳药科大学药学院; |
| |
| 摘 要： | 目的:研究黄芩苷滴丸的制备工艺。方法:以滴丸的圆整度、滴制时的拖尾情况、溶散时限、硬度等为指标,对基质、药物与基质的配比、熔融的温度、滴制温度、冷却剂、冷却温度及冷凝柱的长度进行考察。结果:滴丸最佳制备工艺为最佳基质PEG 6000,药(黄芩苷-PVPK30固体分散体)-基质(质量比)(1∶5),熔融温度为80～90℃,滴制温度为85～90℃,冷凝剂为液体石蜡和植物油1∶1的混合物,冷凝液的温度在10℃左右,冷凝柱长为40 cm。结论:优选得到的黄芩苷滴丸成型工艺稳定可行。
|
| 关 键 词： | 黄芩苷 固体分散体 滴丸 成型工艺 |
Study on formation technology of baicalin dropping pills |
| |
| WANG Yu-xiu,JIA Jin-ping,CHEN Da-wei,QIN Xue-mei,WANG Yu-bi. Study on formation technology of baicalin dropping pills[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(10) |
| |
| Authors: | WANG Yu-xiu JIA Jin-ping CHEN Da-wei QIN Xue-mei WANG Yu-bi |
| |
| Affiliation: | WANG Yu-xiu1,JIA Jin-ping2,CHEN Da-wei3,QIN Xue-mei2,WANG Yu-bi1(1.Shanxi Biological Application Vocational Technical College,Shanxi Taiyuan 030031,China,2.Modern Research Center for Traditional Chinese Medicine of Shanxi University,Shanxi Taiyuan 030006,3.Shenyang Pharmaceutical University,Liaoning Shenyang 110016,China) |
| |
| Abstract: | OBJECTIVE To study on the preparation technology of baicalin dropping pills.METHODS Solid dispersion(SD)of baicalin was prepared with PVPk30.baicalin dropping pills were prepared by dropping method.On the basis of single-factor optimization methods,preparation conditions were selected among sort of matrix,consumption of matrix,the temperature of drug melting,temperature and height of refrigerants and all the procedures were evaluated by the hardness,tailing,scatter time and sphericity of the pills.RESULTS T... |
| |
| Keywords: | baicalin solid dispersion dropping pills forming technology |
| 本文献已被 CNKI 等数据库收录！ |
|
