| 益血口服液对人免疫细胞及小鼠细胞分裂的影响 |
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| 引用本文： | 邓凤祥. 益血口服液对人免疫细胞及小鼠细胞分裂的影响[J]. 中国医院药学杂志, 2011, 0(11) |
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| 作者姓名： | 邓凤祥 |
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| 作者单位： | 暨南大学第二临床医学院深圳市人民医院; |
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| 摘 要： | 目的:研究益血口服液对成人细胞免疫功能及对小鼠骨髓造血细胞有丝分裂的影响。方法:将不同剂量益血宁口服液作用于12名健康男性受试者的外周血淋巴细胞,以氢化可的松为阳性对照,经淋巴细胞转化技术(LTT)处理,以形态学方法考察淋巴细胞转化百分率(LTP);以48只昆明种小鼠分为3组,以丝裂霉素C(MMC)为阳性对照,给药10d后取双侧股骨骨髓细胞,镜检计算其中的有丝分裂指数;同时考察了益血口服液中Fe2+,Zn2+,Cu2+含量。结果:益血口服液对提高细胞免疫功能在此范围有量效关系,对正常状态的动物有促进骨髓造血细胞有丝分裂的作用。结论:本品具有提高细胞免疫功能及促进骨髓造血细胞有丝分裂的作用,Fe2+,Zn2+离子含量较高,可能是其对营养性缺铁性贫血具有治疗效果的药理学基础。
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| 关 键 词： | 益血口服液 人T淋巴细胞 鼠骨髓细胞 有丝分裂 |
Effects of Yixue oral solution on human cellular immune function and mitosis myeloid elements of mice |
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| DENG Feng-xiang. Effects of Yixue oral solution on human cellular immune function and mitosis myeloid elements of mice[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(11) |
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| Authors: | DENG Feng-xiang |
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| Affiliation: | DENG Feng-xiang(The Second Affiliated Hospital,Jinan University Medical College,Shenzhen People's Hospital,Guangdong Shenzhen 518020,China) |
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| Abstract: | OBJECTIVE To investigate the effects of Yixue oral solution on human cellular immune function and mitosis myeloid elements of mice.METHODS Peripheral blood lymphocyte(PBL) from 12 healthy male subjects were added with Yixue oral solution in different contents,and hydrocortisone was used as positive control.PBL was observed by morphology method to investigate lymphocyte transformation percentage(LTP) after lymphocyte transformation test(LTT).48 Kunming mice were divided to 3 groups and administrated with Yix... |
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| Keywords: | Yixue oral solution human lymphocyte bone marrow cell of mice mitosis |
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