| 去甲斑蝥素白蛋白微球在小鼠体内肝靶向作用 |
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| 引用本文： | 陈永顺,吴珍,董永成,杜士明. 去甲斑蝥素白蛋白微球在小鼠体内肝靶向作用[J]. 中国医院药学杂志, 2011, 0(18) |
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| 作者姓名： | 陈永顺 吴珍 董永成 杜士明 |
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| 作者单位： | 湖北医药学院附属太和医院药学部;湖北医药学院附属太和医院消化内科; |
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| 摘 要： | 目的:研究去甲斑蝥素(NCTD)白蛋白微球在小鼠体内的组织分布、体外细胞毒性及肝靶向性。方法:采用体外细胞毒性和体内全身急性毒性试验方法,评价NCTD白蛋白微球的抗肿瘤活性及其生物安全性;通过小鼠尾静脉给药得到各主要药动学参数,并与NCTD注射液组比较得其靶向效率。结果:NCTD白蛋白微球在肝脏和肾脏的靶向效率分别为2.389 1和0.375 4。NCTD白蛋白微球体内外的生物安全性与其注射液比较无显著差异。体外细胞毒性显示其对肿瘤细胞具有特殊亲和力和靶向释药作用。结论:NCTD白蛋白微球具有肝脏靶向性,能降低肾脏分布,提高药物疗效,降低全身不良反应。
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| 关 键 词： | 去甲斑蝥素 白蛋白微球 肝靶向 细胞毒性 |
Study on the liver targeting action of norcantharidin albumin microspheres in mice |
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| CHEN Yong-shun,WU-Zhen,DONG Yong-cheng,DU Shi-ming. Study on the liver targeting action of norcantharidin albumin microspheres in mice[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(18) |
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| Authors: | CHEN Yong-shun WU-Zhen DONG Yong-cheng DU Shi-ming |
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| Affiliation: | CHEN Yong-shun1,WU-Zhen2,DONG Yong-cheng1,DU Shi-ming1 (Taihe Hospital affiliated to Hubei University of Medicine,1.Department of pharmacy,2.Deparement of Gastroenternology,Hubei Shiyan 442000,China) |
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| Abstract: | OBJECTIVE To study the distribution,biological reliability and liver targeting action of norcantharidin(NCTD) albumin microspheres in mice. METHODS The anti-tumor action of norcantharidin NCTD albumin microspheres were evaluated by cytotoxicity testing in vitro and the biological safety was evaluated by acute toxicity testing.The concentration of NCTD in plasma and tissues were determined by HPLC method.The data obtained were processed using 3P97 program. RESULTS Targeting efficiency of NCTD albumin microsp... |
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| Keywords: | norcantharidin albumin microspheres liver targeting cytotoxicity |
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