| 伊立替康联合草酸铂、5-氟尿嘧啶、亚叶酸钙治疗晚期胃癌的临床疗效 |
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| 引用本文： | 梁新亮,罗执芬,马宁,崔永霞,周建炜,仓顺东,白冰,周云.伊立替康联合草酸铂、5-氟尿嘧啶、亚叶酸钙治疗晚期胃癌的临床疗效[J].中国医院药学杂志,2011(15). |
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| 作者姓名： | 梁新亮 罗执芬 马宁 崔永霞 周建炜 仓顺东 白冰 周云 |
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| 作者单位： | 河南省人民医院; |
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| 摘 要： | 目的:比较伊立替康联合奥沙利铂和5-氟尿嘧啶、亚叶酸钙(FOLFOXIRI)与奥沙利铂联合CF,5-FU(FOLFOX4)治疗进展期或转移性胃癌的疗效和毒副反应。方法:经病理确诊的进展期或转移性胃癌患者78人,随机分为两组,FOLFOXIRI组36人,FOLFOX6组42人。FOLFOX4方案:L-OHP 85 mg/m2,第1天静滴,CF 200 mg/m2,5-FU 400 mg/m2,静冲,5-FU 600mg/m2,第1,2天,持续静点22h。FOLFOXIRI方案用法:CPT-11 165 mg/m2,L-OHP,CF,5-FU用法同FOLFOX4。结果:FOL-FOXIRI方案与FOLFOX4方案一线治疗进展期或转移性胃癌的缓解率分别为53.07%和28.57%(P=0.028),中位生存期分别为11.8月和9.4月(P=0.321),中位疾病进展时间为6.0月和4.8月(P=0.036)。FOLFOXIRI方案的骨髓毒性和腹泻发生率高于FOLFOX4方案。结论:本研究结果显示FOLFOXIRI方案治疗胃癌近期缓解率高于FOLFOX4方案,不良反应可以耐受,值得更深入系统地进行临床研究。
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| 关 键 词： | 胃癌 伊立替康 奥沙利铂 化疗 |
Effect of intravenous infusion of fluorouracil,leucovorin,oxaliplatin and irinotecan(FOLFOXIRI)as first line treatment for advanced gastric cancer |
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| LIANG Xin-liang,LUO Zhi-fen,MA Ning,CUI Yong-xia,ZHOU Jian-wei,CANG Shun-dong,BAI Bing,ZHOU Yun.Effect of intravenous infusion of fluorouracil,leucovorin,oxaliplatin and irinotecan(FOLFOXIRI)as first line treatment for advanced gastric cancer[J].Chinese Journal of Hospital Pharmacy,2011(15). |
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| Authors: | LIANG Xin-liang LUO Zhi-fen MA Ning CUI Yong-xia ZHOU Jian-wei CANG Shun-dong BAI Bing ZHOU Yun |
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| Institution: | LIANG Xin-liang,LUO Zhi-fen,MA Ning,CUI Yong-xia,ZHOU Jian-wei,CANG Shun-dong,BAI Bing,ZHOU Yun(Henan Provincial People's Hospital,Henan Zhengzhou 450003,China) |
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| Abstract: | OBJECTIVE To compare the efficacy and toxicity of irinotecan(CPT-11),in combination with oxaliplatin(L-OHP),5-fluorouracil(5-FU) and leucovorin(LV)(FOLFOXIRI) vs oxaliplatin and 5-FU/LV(FOLFOX4) as first-line treatment in patients with advanced or metastatic gastric cancer.METHODS A total of 78 chemotherapy-na ve patients with advanced or metastatic gastric cancer were enrolled(FOLFOXIRI arm: n=36;FOLFOX4 arm: n=42).In the FOLFOXIRI arm,CPT-11(165 mg/m2) was given on d1,L-OHP(65 mg/m2) on d2,LV(200 mg/m2) o... |
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| Keywords: | gastric cancer irinotecan oxaliplatin chemotherapy first-line treatment |
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