白藜芦醇对大鼠脊髓损伤早期能量代谢的影响

目的：探讨白藜芦醇（RES）在脊髓损伤（SCI）早期对细胞色素C氧化酶（COX）和超氧化物歧化酶（SOD）活性的影响。方法：2008年2月~2008年8将54只SD健康成年雄性大鼠随机分成3组,根据Allen＇s法制成中度脊髓损伤模型,术后立即管饲白藜芦醇100mg/kg或甲基强的松龙（MPSS）100mg/kg;通过比色法观察脊髓损伤8、24及72h后白藜芦醇组脊髓COX及SOD活性的变化,并与MPSS（甲基强的松龙）组进行疗效对比。结果：在脊髓损伤后8、24及72h白藜芦醇组COX活性与损伤组比较差异均有统计学意义,显示白藜芦醇对脊髓损伤具有明显干预作用,而且白藜芦醇组与MPSS组间仅损伤后72h差异无统计学意义（P〉0.05）;SOD活性在脊髓损伤后8、24及72h白藜芦醇组及MPSS组与损伤组比较差异均有统计学意义,表明白藜芦醇可以提高SOD活性,但在脊髓损伤后8及72h白藜芦醇组与MPSS组比较差异无统计学意义（P〉0.05）,损伤后24h两者间比较差异有统计学意义。结论：白藜芦醇在脊髓损伤早期能够有效上调COX和SOD活性,对损伤后脊髓起保护作用。

Effects of Resveratrol on the Expression of Cytochrome C and Superoxide Dismutase in the Early Periodof Spinal Cord Injury of Rats

Objective:To investigate the effect of resveratrol on the activity of cytochrome C and superoxide dismutase in early period of spinal cord injury.Methods:Fifty-four adult male Sprague-dawley rats were randomly divided into 3 groups in the animal department of Renmin Hospital of Wuhan Univeristy from February 2008 to August 2008.Established moderate spinal cord injury animal model by Allen's method.Then the resveratrol(100mg/kg) or methylprednisolone(MPSS,100mg/kg) was fed immediately by tube feeding.The cha...