| 重组人粒细胞巨噬细胞集落刺激因子凝胶对烧伤后残余创面的促愈合作用 |
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| 引用本文： | 邱学文,王甲汉,杨磊,任加良.重组人粒细胞巨噬细胞集落刺激因子凝胶对烧伤后残余创面的促愈合作用[J].中国医院药学杂志,2011(10). |
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| 作者姓名： | 邱学文 王甲汉 杨磊 任加良 |
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| 作者单位： | 南方医科大学南方医院烧伤科; |
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| 摘 要： | 目的:探讨局部应用重组人粒细胞巨噬细胞集落刺激因子(rhGM-CSF)凝胶对烧伤后残余创面愈合的影响。方法:采用随机、双盲、安慰剂同体对照的研究方法,将120处烧伤后残余创面,随机分为试验组(n=60)和对照组(n=60)。试验组采用rhGM-CSF凝胶治疗,对照组采用空白基质安慰剂治疗,试验周期为21 d。观察用药后7,14 d的创面愈合率以及愈合时间,病理学观察创面肉芽组织中毛细血管数和纤维母细胞数,免疫组化检测创面增殖细胞核抗原(PCNA)的表达。结果:用药7,14 d后,试验组创面愈合率分别为(62±13)%,(95±10)%,均显著高于对照组(46±11)%,(83±12)%(P<0.01);试验组创面平均愈合时间为12.6 d95%可信区间(11.9～13.3)d],较对照组16.8 d95%可信区间(16.1～17.5)d]明显缩短(P<0.01)。用药7,14 d后,试验组创面肉芽组织中毛细血管数分别为(10.3±0.6),(14.5±0.9),均显著多于对照组(7.2±0.7),(10.4±0.8)(P<0.01);试验组创面肉芽组织中纤维母细胞数分别为(143.1±10.3),(137...
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| 关 键 词： | 烧伤 粒细胞巨噬细胞集落刺激因子 创面愈合 |
Healing-promoting effects of recombinant human granulocyte-macrophage colony-stimulating factor gel on residual burn wounds |
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| QIU Xue-wen,WANG Jia-han,YANG Lei,REN Jia-liang.Healing-promoting effects of recombinant human granulocyte-macrophage colony-stimulating factor gel on residual burn wounds[J].Chinese Journal of Hospital Pharmacy,2011(10). |
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| Authors: | QIU Xue-wen WANG Jia-han YANG Lei REN Jia-liang |
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| Institution: | QIU Xue-wen,WANG Jia-han,YANG Lei,REN Jia-liang(Department of Burns,Nanfang Hospital,Southern Medical University,Guangdong Guangzhou 510515,China) |
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| Abstract: | OBJECTIVE To investigate the effects of recombinant human granulocyte-macrophage colony-stimulating factor(rhGM-CSF) gel on residual burn wound healing.METHODS The study was a randomized,double-blind,placebo-controlled and self-controlled clinical trial.One hundred and twenty residual burn wounds were divided into group A(n=60,with treatment of rhGM-CSF gel) and group C(n=60,with treatment of placebo),the patients were treated for 21 days totally.Wound healing rate on 7th,14th day after treatment and wound ... |
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| Keywords: | burns granulocyte-macrophage colony-stimulating factor wound healing |
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