盐酸纳洛酮在心肺脑复苏急诊抢救中的应用

目的探讨盐酸纳洛酮对不同原因所致心跳呼吸骤停患者心肺脑复苏的治疗作用。方法将心脑血管疾病、各种中毒、休克、电击、窒息及原因不明的心跳呼吸骤停患者随机分为纳洛酮组及对照组各25例。2组均给予心外按压、气管插管、机械通气、电击除颤、静脉用药(肾上腺素、阿托品、利多卡因等)及支持对症治疗。纳洛酮组除上述治疗措施外,同时给予盐酸纳洛酮2.0 mg加入5%葡萄糖或0.9%氯化钠液250 m l中静脉滴注,观察2组心肺脑复苏情况。结果纳洛酮组25例复苏成功17例,成功率68.0%;对照组25例,复苏成功10例,成功率40.0%。纳洛酮组复苏成功率明显高于对照组,2组比较经统计学处理有显著差异。结论纳洛酮能有效地应用于心跳呼吸骤停患者的心肺脑复苏,能显著提高心肺脑复苏的抢救成功率。

Application of Naloxone in cardiopulmonary cerebral resuscitation

Objective Probing the curative effect of Naloxone in cardiopulmonary cerebral resuscitation(CPCR) for all kinds of cardiopulmonary arrests by different cause of disease.Methods The patients who are under cardiopulmonary arrests with cardiac or/and cerebral vascular disease,in all kinds of poisoning,in shock,injured by electricity,stifled or with no obvious cause were divided into two groups in random.Each group had 25 samples.The patients in one group were treated with Naloxone;those in the compared group were not.Both of the two group members were treated with external chest compressions,endotracheal intubations,machine ventilation,defibrillation,drugs by I.V.routes(Epinephrine,Atropine,Lidocaine and so on),supporting and suiting remedy to the illness.The patients of the group with Naloxone were given Naloxone I.V.dripped in 5% glucose or 0.9% sodium chloride injection(250ml).Then we observed the reactions in CPCR of two group patients.Results There are 17 patients made successful recoveries in the group with naloxone(the success ratio:68.0%),while there were 10 patients made successful recoveries in the compared group(the success ratio:40.0%).The success ratio in resuscitation of the group with naloxone was obvious higher than that in the compared group.There was a remarkable difference between the two groups by dealing through statistical method.Conclusions Naloxone can work efficiently when applied in CPCR for cardiopulmonary arrests.It can enhance the success ratio in CPCR remarkably.