TRANSFERRIN C SUBTYPES IN PATIENTS WITH RHEUMATOID ARTHRITIS |
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| Authors: | EL-HAZMI, M. A. F. AL-BALLAA, S. R. WARSY, A. S. AL-ARFAJ, H. AL-SUGHAIR, S. AL-DALAAN, A. N. |
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| Affiliation: | *Medical Biochemistry Department, College of Medicine, King Saud University Riyadh, Saudi Arabia
!["{dagger}"]("/math/dagger.gif") Department of Medicine, College of Medicine, King Saud University Riyadh, Saudi Arabia
!["{ddagger}"]("/math/Dagger.gif") Department of Biochemistry, College of Science, King Saud University Riyadh, Saudi Arabia
¶Department of Medicine, King Faisal Specialist Hospital & Research Centre Riyadh, Saudi Arabia |
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| Abstract: | Transferrin (TF) subtypes were investigated in 128 patientswith rheumatoid arthritis (RA) and the frequencies of TfC subtypeswere compared with the results in normal individuals. The frequenciesof the Tf genes: C1, C2, C3, D1, and D2 were 0.4765, 0.3867,0.0742, 0.0390 and 0.0234, respectively. The frequency of TfC2gene was significantly higher in these patients (0.3867) comparedto the value in the control group (C2 = 0.247). The relativerisk of RA in association with TfC1C2 type was 2.0, while itwas 0.18 in association with TfC1C1 type and the results werestatistically significant. This paper confirms the significant association between TfC2and RA. Furthermore, it appears from our results that TfC1 homozygousphenotype is protective for the development of RA. The resultsare discussed in the light of earlier suggestions that the TfC2subtype confers an increased risk of cellular damage by enhancinghydroxyl radical formation, although it is possible that thereexists a genetic linkage of Tf variant to some other locus whichis influencing susceptibility to RA. KEY WORDS: Iron transport, Spontaneous abortion, Hydroxyl-radical formation, Oxygen-derived free radicals, Isoelectric focusing, Holotransferrin |
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