膀胱癌P21、P53、nm23蛋白表达的临床意义

目的探讨癌基因与抑癌基因表达与膀胱癌生物学行为的关系.方法应用免疫组化方法对48例膀胱移行细胞癌中P21、P53、nm23蛋白进行检测.结果P21、P53、nm23蛋白表达的阳性率分别是58.3%、47.9%、41.7%.P21、P53蛋白表达阳性率与肿瘤分级、分期及复发呈正相关.nm23蛋白表达阳性率与分级呈正相关,与分期及复发呈负相关.77.1%膀胱癌有上述蛋白异常表达,其中47.9%膀胱癌同时有两个或两个以上蛋白表达.结论癌基因及抑癌基因的异常表达及协同作用,在膀胱癌发生、发展中起重要作用.

EXPRESSION OF P21, P53 AND nm23 PROTEINS IN BLADDER CARCINOMA AND ITS CLINICAL SIGNIFICANCE

Objective:To explore the relationship between the expression of the oncogenes and antioncogenes of bladder carcinoma and its biological characteristic.Methods:The expression of P21?P53 and nm23 proteins in 48 cases of transitional cell carcinoma of bladder was determined with immunohistochemistry.Results:The positive rates of expression for P21,P53 and nm23 proteins were 58.3%,47.9% and 41.7% respectively.The positive rates of expression of P21 and P53 were positively correlated to pathological grade,clinical stage and recurrence.The positive rate of expression of nm23 was positively correlated to pathological grade and negatively correlated to clinical stage and recurrence.There was 77.1% expression in one or more oncogenes and (or) antioncogenes.Multiple oncogene and (or)antioncoge common expression was found in 47.9%.Conclusion:Abnormal expression and synergistic action of oncogenes and antioncogenes play an important role in occurrence and development of bladder carcinoma.