准分子激光上皮下角膜磨镶术中联合应用丝裂霉素C临床效果观察

目的：观察准分子激光上皮下角膜磨镶术（laser epithelial keratomileusis,LASEK）术中联合应用丝裂霉素C的临床效果。方法：回顾性分析我院2009年7月至2010年3月行LASEK手术的患者55例110只眼,其中男23例46只眼,女32例64眼,平均球镜当量为（-7.78±2.09）D（-14.5～4.25 D）,术中滴入0.2%丝裂霉素（mitomycin-C,MMC）,浸润12 s后立即吸干,5 ml BBS冲洗。术后随访3个月。分析裸眼视力术后、并发症发生情况。结果：LASEK手术后平均裸眼视力1个月为0.95±0.19,2个月为1.01±0.14,3个月为1.09±0.13;电脑验光屈光度术后1个月为0.66±1.07,2个月为0.28±0.28,3个月为0.23±0.92（P均〈0.05）,术后1个月、2个月、3个月的≥1.0视力情况分别为77.27%、90.00%、98.18%;术后3个月视力恢复明显（P〈0.05）。术后角膜雾状混浊（HAZE）发生时间最早为11 d,最晚为129 d,平均35 d;术后3个月HAZE分级分别为0级占80%、0.5级占18%、1级占2%。结论：LASEK手术术中联合应用MMC矫正中低高度近视、超高度近视是安全、有效的。

Clinical Observation on the Clinical Efficacy by Using Mitomycin-C in Laser Epithelial Keratomileusis

Objective:To assess the efficacy of using mitomycin-C(MMC) in laser epithelial keratomileusis(LASEK).Method:LASEK combined with mitomycin-C was performed in 55 myopia patients(110 eyes),male 46 cases,female 64 cases,mean manifest refraction spherical equivalent(MRSE) was(-7.78±2.09)D(-14.5～4.25 D),naked visual acuitys and the grade of the HAZE were analyzed.Result:At 1,2 and 3 months,naked visual acuity was 0.95±0.19,1.01±0.14,1.09±0.13(P<0.05),refractive power by computer optometry was 0.66±0.07,0.28±0.28,0.23±0.92(P<0.05).Naked visual acuity more than 1.0 was 77.27%,90.00% and 98.18%.At 3 months,the grade 0,0.5 and 1 of HAZE was 80%,18% and 12%.Conclusion:Using MMC in LASEK was safe and effect for myopic patients.