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| 高效液相色谱法同时测定复方氨氯地平片中苯磺酸氨氯地平和赖诺普利的含量 | |
| 引用本文： | 相文杰,叶 靖,田志杰,韩 洁,姚 静.高效液相色谱法同时测定复方氨氯地平片中苯磺酸氨氯地平和赖诺普利的含量[J].药学与临床研究,2012,20(3):270-272. |
| 作者姓名： | 相文杰 叶 靖 田志杰 韩 洁 姚 静 |
| 作者单位： | 1. 南京瑞尔医药有限公司,南京,210061 2. 南京泽恒医药技术开发有限公司,南京,210028 3. 中国药科大学药剂教研室,南京,210009 |
| 摘 要： | 目的:以高效液相色谱法同时测定复方氨氯地平片中苯磺酸氨氯地平和赖诺普利的含量。方法:采用高效液相色谱法梯度洗脱的方法,以赛分C18色谱柱,流速1.8 mL.min-1,检测波长210 nm为测定色谱条件。结果:苯磺酸氨氯地平和赖诺普利测定的线性范围分别为10～200μg.mL-1和20～400μg.mL-1,线性方程分别为Y=20.40X-0.1036和Y=38.17X+4.470;苯磺酸氨氯地平和赖诺普利平均回收率(n=9)分别为100.8%±0.78%和101.3%±0.60%。结论:本方法准确、快速,适合复方氨氯地平片中药物含量的同时检测。 |
| 关 键 词： | 苯磺酸氨氯地平 赖诺普利 含量测定 |
| 收稿时间： | 2012/3/15 0:00:00 |
| 修稿时间： | 2012/4/6 0:00:00 |
HPLC Determination of Amlodipine Besylate and Lisinopril in Compound Amlodipine Tablets |
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| XIANG Wen-jie,YE Jing,TIAN Zhi-jie,HAN Jie and YAO Jing.HPLC Determination of Amlodipine Besylate and Lisinopril in Compound Amlodipine Tablets[J].Pharmacertical and Clinical Research,2012,20(3):270-272. | |
| Authors: | XIANG Wen-jie YE Jing TIAN Zhi-jie HAN Jie and YAO Jing |
| Institution: | 1Nanjing REAL Pharmaceutical Co.,Ltd.,Nanjing 210061; 2Nanjing Zeheng Pharmaceutical Science & Technology CO.,Ltd.,Nanjing 210028; 3China Pharmaceutical University,Nanjing 210009,China |
| Abstract: | Objective: To establish an HPLC method for determining amlodipine besylatete and lisinopril in compound amlodipine tablets.Methods: HPLC analysis was carried out by gradient elution.The flow rate was 1.8 mL·min-1,and the detection wavelength was 210 nm.Results: The calibration curves for amlodipine and lisinopril were linear between the ranges of 10～200 μg·mL-1 and 20～400 μg·mL-1,respectively.The average recoveries(n=5) were 100.8%±0.78% and 101.3%±0.60%.Conclusion: This method is accurate,convenient and suitable for determining amlodipine besylatet and lisinopril simultaneously. |
| Keywords: | Amlodipine Lisinopril Determination |
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