| Aurora激酶抑制剂研究进展 |
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| 引用本文： | 冷 莹,袁浩亮,张微微,陈亚东,陆 涛. Aurora激酶抑制剂研究进展[J]. 药学与临床研究, 2012, 20(3): 211-217 |
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| 作者姓名： | 冷 莹 袁浩亮 张微微 陈亚东 陆 涛 |
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| 作者单位： | 中国药科大学基础部分子设计与药物发现实验室,南京,210009 |
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| 摘 要： | Aurora激酶是细胞有丝分裂相关的一类丝氧酸/苏氨酸激酶,在细胞周期调控中起着重要的作用,研究发现Aurora激酶在多数血液恶性肿瘤和实体瘤中均高表达,表明Aurora激酶是抗肿瘤药物研究的重要新靶点之一.本文主要围绕Aurora家族的三个成员,对其生物学功能及其与肿瘤的关系、抑制剂的研究进展及其研究策略进行综述.
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| 关 键 词： | Aurora激酶 有丝分裂 Aurora激酶抑制剂 癌症治疗 |
| 收稿时间： | 2012-03-05 |
| 修稿时间： | 2012-03-15 |
Progress in the Development of Aurora Kinase Inhibitors |
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| LENG Ying,YUAN Hao-liang,ZHANG Wei-wei,CHEN Ya-dong and LU Tao. Progress in the Development of Aurora Kinase Inhibitors[J]. Pharmacertical and Clinical Research, 2012, 20(3): 211-217 |
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| Authors: | LENG Ying YUAN Hao-liang ZHANG Wei-wei CHEN Ya-dong LU Tao |
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| Affiliation: | Laboratory of Molecular Design and Drug Discovery,School of Basic Sciences,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | Aurora kinases belong to serine/threonine kinase family,which are involved in cellular mitosis affecting the process of cell cycle.Several studies have shown amplification and/or over-expression of Aurora kinase in hematologic malignancies and solid tumors,suggesting they are important targets for anti-cancer drugs.This review summarized the biological functions of Aurora kinases,their relationship with tumor,the progresses and development strategy of Aurora kinase inhibitors. |
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| Keywords: | Aurora kinase Mitosis Aurora kinase inhibitors Cancer therapy |
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