深圳市淋球菌分离株抗生素耐药性分析

目的 了解广东省深圳市淋病双球菌对抗生素的耐药性及产β内酰胺酶淋病双球菌(PPNG)和高水平耐四环素淋病双球菌(TRNG)的流行状况.方法 采用琼脂稀释法测定5种抗生素对240株淋病双球菌的最低抑菌浓度(MIC);用改良碘定量法检测PPNG菌株.结果 淋病双球菌对青霉素、四环素、环丙沙星及头孢三嗪的耐药率分别为71.67%,78.33%,37.50%及6.67%;检出32株PPNG菌株,占13.33%;检出30株TRNG菌株占12.5%;同时对青霉素、四环素、环丙沙星耐药的菌株占31.67%.结论 壮观霉素、头孢三嗪仍可作为深圳市治疗淋病的首选用药,但淋球菌对四环素及青霉素的耐药率较高.

Antibiotic resistance of Neisseria gonorrhoeae in Shenzhen

Objective To survey the antibiotic resistance and the prevalence for penicillina seproducing Neisseria gonorrhoeae(PPNG)and potential tetracy cline resistance of Neisseria gonorrhoeae(TRNG)in Shenzhen.Methods Min miuminhibitory concentration(MIC)to 240 strains Neisseria gonorrhoeae of penicillin,tetracyc line,cipro floxacin,speeotinomy cinand ceferiaxone were determined with agard ilution method.PPNG strain swere determined with m dified quantitative iodine method.Results The percentage Neisseria gonor rhoeae strains resisteant to penicillin,tetracy cline,cipro floxac in and ceferi axone was 7.67%,78.33%,37.50%,and 667%,respectively.There were 32(13.33%)PPNG strains and 30(12.5%)TRNGstrains.31.67% of theiso lates were smiultaneously resistant to penic llin,tetracy cline and cipro floxacin.Conclusion Ceferiaxone and speeotinomy cin could be given the priority to treat patients with Neisseria gonor rhoeae.There sistant strains of Neisseria gonorrhoeae to penicillin and tetracyc line are prevalent.