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Renal involvement in ANCA associated vasculitis |
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| Authors: | Subramanian Shankar Abhishek Pathak Rohit Tewari |
| Institution: | 1. Department of Internal Medicine, Armed Forces Medical College, Pune 411040, India;2. Department of Pathology, Armed Forces Medical College, Pune 411040, India;1. Department of Rheumatology, Apollo Hospital, Bhubaneswar, Odisha 751005, India;2. Department of Dermatology, Apollo Hospital, Bhubaneswar, Odisha 751005, India;1. Max Super Specialty Hospital, Patparganj, New Delhi, India;2. Department of Rheumatology, ISIC Superspeciality Hospital, Vasant Kunj, New Delhi, India;3. A&R Clinic, Flat 2015, Sector B-2, Vasant Kunj, New Delhi 110070, India |
| Abstract: | Kidney is involved in upto 75–80% of various ANCA associated vasculitis (AAV) and remains the major cause of mortality and morbidity. The classic clinical presentation is that of rapidly progressive renal failure with cresenteric glomerulonephritis being its pathologic correlate. ANCA positivity has been implicated in the pathogenesis and is useful for diagnosis.The treatment of renal AAV involves the use of steroids in combination with other immunosuppressive agents like cyclophosphamide to induce remission followed by maintenance therapy with a less potent agent like azathioprine. Plasmapharesis has a definite role especially in presence of renal failure while Rituximab is emerging as a promising alternative for remission induction. |
| Keywords: | ANCA associated vasculitis Renal involvement Rapidly progressive glomerulonephritis Rapidly progressive renal failure |
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