联合检测肌钙蛋白T、高敏C反应蛋白和B型钠尿肽对非ST段抬高的急性冠状动脉综合征预后诊断的价值

目的探讨联合检测肌钙蛋白T、高敏C反应蛋白、B型钠尿肽对非ST段抬高的急性冠状动脉综合征预后诊断的价值。方法检测145例经冠状动脉造影证实的非ST段抬高的急性冠状动脉综合征患者肌钙蛋白T、高敏C反应蛋白、B型钠尿肽的水平。随访急性冠状动脉综合征患者12个月，观察终点为心肌梗死新发或再发和心源性死亡。结果多因素logistic回归分析发现肌钙蛋白T、高敏C反应蛋白、B型钠尿肽可独立预测非ST段抬高急性冠状动脉综合征患者远期预后。经过已知的临床危险因素校正后，心脏生化标志物异常的数目仍然是其心血管事件重要危险因子。结论联合检测肌钙蛋白T、高敏C反应蛋白、B型钠尿肽对急性冠状动脉综合征患者长期预后有重要的临床价值。

The Prognostic Value of Measurements of Troponin T,High Sensitive C-Reactive Protein,and B-Type Natriuretic Peptide in Patients with Non-ST Elevation Acute Coronary Syndromes

Aim To explore the prognostic value of measurements of Troponin T(TnT),high sensitive C-reactive protein(hs-CRP),and B-type natriuretic peptide(BNP)in patients with non-ST elevation acute coronary syndrome(ACS).Methods Levels of serum TnT,hs-CRP,and BNP were measured among 145 ACS patients verified by coronary angiography.Patients with ACS were followed up 12 months.The end point was cardiac events including new or recurrent myocardial infarction(MI)and cardiac death.Results The multivariate Logistic regression mode analysis revealed that TnT,hs-CRP,and BNP were independent long-term prognostic markers in patients with non-ST elevation ACS.The number of elevated biomarkers remained a significant predictor of the composite endpoint after adjustment for known clinical predictors.Conclusions Measurements of TnT,hs-CRP,and BNP had practical significance in evaluating the long-term outcome of non-ST elevation ACS.