临床药师干预对门诊晚期癌症患者疼痛治疗的影响

目的探讨临床药师在门诊晚期癌症患者疼痛治疗中的作用。方法采用随机对照法，收集病例为2012年12月至2013年5月，在我院门诊建立麻醉药品取用卡的晚期癌痛患者101例，分为实验组和对照组。实验组实施技术干预，对照组不予技术干预。每位患者随访1个月后，分别评估其疼痛强度、生活质量、用药依从性和回顾监测ADR，并对结果进行比较研究。结果两组患者在疼痛强度、用药依从性方面差异有统计学意义，部分生活质量指标（疼痛、认知、情绪、疲倦、恶心、呕吐、便秘及总体健康状况）和部分不良反应（恶心、呕吐、便秘）差异也有统计学意义；而阿片类药物使用剂量和部分生活质量指标（躯体功能、角色功能、社会功能、气促、失眠、食欲、腹泻、经济困难）差异无统计学意义。结论临床药师对门诊晚期癌症患者疼痛治疗的干预，能提高患者用药合理性、用药安全性和用药依从性，能有效缓解患者癌痛，改善其生活质量。

Clinical pharmacist intervention effects on analgesic treatment of outpatients with terminal cancer

AIM To explore the role of clinical pharmacists in the analgesic treatment of cancer outpatients. METHODS This was a randomized and controlled study. A total of 101 cases of terminal cancer outpatients in our hospital with a card about narcotic drugs from December 2012 to May 2013, were divided into the trial group and the control group. The trial group was given technological intervention treatment while the control group was not. After one-month follow-up, clinical pharmacists respectively evaluated terminal cancer patients＇ pain relief, quality of life, medication compliance, and monitoring review of adverse drug reactions, and compared the results. RESULTS There was statistic significance between 2 groups in pain relief, medication compliance, some quality of life indexes （pain, cognition, emotion, fatigue, nausea, vomiting, constipation and overall health status） and some indexes of adverse drug reactions （nausea, vomiting and constipation） （ P 〈 0.05）, whereas there was no significant difference in using doses about opioid drugs as well as some quality of life indexes （somatic function, role function, social function, polypnea, insomnia, appetite, diarrhea and economic difficulties）. CONCLUSION Through the intervention treatment of outpatients with terminal cancer pain, clinical pharmacists could not only significantly improve patients＇ medication safety, medication compliance and the quality of life but also effectively alleviate the cancer patients＇ pain, and quality of life.