| 骨形态发生蛋白2/4 在神经系统中的作用及其研究进展 |
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| 引用本文： | 杨林,徐军美,王亚平,王鑫. 骨形态发生蛋白2/4 在神经系统中的作用及其研究进展[J]. 中南大学学报(医学版), 2018, 43(2): 222-228. DOI: 10.11817/j.issn.1672-7347.2018.02.020 |
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| 作者姓名： | 杨林 徐军美 王亚平 王鑫 |
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| 作者单位： | 中南大学湘雅二医院麻醉科,中南大学麻醉医学研究所,长沙 410011 |
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| 基金项目： | 湖南省科技厅重点研发项目(2015SK2085)。 |
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| 摘 要： | 骨形态发生蛋白(bone morphogenetic proteins,BMPs)属于转化生长因子-β(transforming growth factor β,TGF-β)超家族,在心、神经、软骨的发育以及出生后骨的形成等发育过程中均起重要的调节作用。近年来的研究表明：在各类BMPs分子中,BMP2/4参与并促进了发育期和成熟期的中枢神经系统内神经元与胶质细胞的发育与激活,且在特定的环境中发挥不同甚至相反的生物学作用,这种差异性为其临床应用带来了一定的风险。
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| 关 键 词： | 骨形态发生蛋白 中枢神经系统 神经胶质细胞 神经损伤 神经病理性疼痛 |
Progress in the study on bone morphogenetic protein 2/4 in central nervous system |
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| YANG Lin,XU Junmei,WANG Yaping,WANG Xin. Progress in the study on bone morphogenetic protein 2/4 in central nervous system[J]. Journal of Central South University. Medical sciences, 2018, 43(2): 222-228. DOI: 10.11817/j.issn.1672-7347.2018.02.020 |
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| Authors: | YANG Lin XU Junmei WANG Yaping WANG Xin |
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| Affiliation: | Department of Anesthesiology, Second Xiangya Hospital; Institute of Anesthesiology, Central South University, Changsha 410011, China |
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| Abstract: | As a member of transforming growth factor β (TGF-β) family, bone morphogenetic proteins(BMPs) are multi-functional factors and play critical roles in heart, cartilage, neural developmentand postnatal bone formation. It has been demonstrated that among the family, BMP2/4 have beenreported to be especially important for the developmental and maturation of central nervous system(CNS). It has diff erent, even opposite functions, in certain given circumstances, which could be apotential risk for BMPs’ clinical use. |
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