乳酸脱氢酶 -5 在非霍奇金淋巴瘤中的表达及其临床意义

目的：探讨乳酸脱氢酶同工酶(lactate dehydrogenase，LDH)-5在非霍奇金淋巴瘤中的表达及其临床意义。 方法：利用琼脂糖凝胶电泳法及酶促法分别对63 例非霍奇金淋巴瘤患者的LDH及LDH-5表达水平进行检测，对两组 阳性例数进行比较。结果：63例患者的中位发病年龄为56(19~84)岁，男36例，女27例。初治组43例LDH及LDH-5总 阳性例数比较差异有统计学意义(P<0.05)，其中22例弥漫大B细胞淋巴瘤及9例T细胞淋巴瘤LDH-5阳性例数明显多于 LDH(P<0.05)，而12例小B细胞淋巴瘤LDH及LDH-5阳性例数比较差异无统计学意义(P>0.05)；疾病进展组29例LDH及 LDH-5总阳性例数比较差异无统计学意义(P>0.05)；疾病复发组15例LDH及LDH-5总阳性例数比较差异无统计学意义 (P>0.05)，但11例小B细胞淋巴瘤LDH-5的阳性例数明显多于LDH(P<0.05)。结论：LDH-5可作为非霍奇金淋巴瘤判断 肿瘤侵袭性、预测复发的指标。

Expression of lactate dehydrogenase-5 in non-Hodgkin lymphoma and its clinical significance

Objective: To determine expression of lactate dehydrogenase (LDH)-5 in non-Hodgkin lymphoma and its clinical signifi cance. Methods: LDH-5 levels and LDH levels in NHL patients were examined by agarose gel electrophoresis and enzymatic method (n=63), respectively. Positive rates of LDH-5 and LDH were statistically analyzed. Results: The median age of NHL patients was 56(19–84) years old, including 36 males and 27 females. The positive numbers for LDH-5 and LDH in the initial treatment group (n=43) were signifi cantly diff erent (P<0.05). Th ere was signifi cant diff erence in 22 cases of diff use large B cell lymphoma and in 9 cases of T cell lymphoma, whereas there was not significant difference in 12 cases of small B cell lymphoma (P>0.05). In 15 cases under the status of progress, the difference of LDH-5 and LDH expressions were not significant (P>0.05), whereas the difference in cases of small B cell lymphoma was significant (P<0.05). Conclusion: LDH-5 can be used as an index for NHL to judge the tumor load and to predict the recurrence.