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| 布南色林和鲁拉西酮改善精神分裂症患者认知功能的机制及临床应用研究进展 | |
| 引用本文： | 郑琪,刘帮杉,徐抒音,廖梅,张燕,李凌江. 布南色林和鲁拉西酮改善精神分裂症患者认知功能的机制及临床应用研究进展[J]. 中南大学学报(医学版), 2017, 42(4): 476-480. DOI: 10.11817/j.issn.1672-7347.2017.04.018 |
| 作者姓名： | 郑琪 刘帮杉 徐抒音 廖梅 张燕 李凌江 |
| 作者单位： | 1. 中南大学湘雅二医院精神卫生研究所，国家精神心理疾病临床研究中心，精神疾病诊疗技术工程实验室， 湖南省精神病学与精神卫生重点实验室，长沙 410011；2. 中南大学基础医学院人体解剖与神经生物学系，长沙 410013 |
| 摘 要： | 认知功能障碍是精神分裂症常见症状之一，主要表现为抽象思维、记忆、注意等方面的障碍。认知功能的改善对患者疾病康复、社会功能恢复具有至关重要的意义。近来研究表明新型非典型抗精神病药物布南色林和鲁拉西酮具有独特的受体作用机制，有望使患者认知功能障碍得到更好的改善。笔者从精神分裂症患者认知功能障碍的病因机制入手，综述布南色林和鲁拉西酮改善精神分裂症患者认知功能的作用机制；介绍两种药物的临床应用进展，以便更好地指导临床用药，为进一步研究提供新方向。 |
| 关 键 词： | 精神分裂症 认知功能 布南色林 鲁拉西酮 |
Research progress in mechanisms and clinical application#br#for blonanserin and lurasidone in improving cognitive#br#function of schizophrenia |
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| ZHENG Qi,LIU Bangshan,XU Shuyin,LIAO Mei,ZHANG Yan,LI Lingjiang. Research progress in mechanisms and clinical application#br#for blonanserin and lurasidone in improving cognitive#br#function of schizophrenia[J]. Journal of Central South University. Medical sciences, 2017, 42(4): 476-480. DOI: 10.11817/j.issn.1672-7347.2017.04.018 | |
| Authors: | ZHENG Qi LIU Bangshan XU Shuyin LIAO Mei ZHANG Yan LI Lingjiang |
| Affiliation: | 1. Mental Health Institute, Second Xiangya Hospital, Central South University; National Clinical Research Center for Mental Disorder; National Technology Institute of Psychiatry; Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha 410011; 2. Department of Human Anatomy and Neuroscience, School of Basic Medicine, Central South University, Changsha 410013, China |
| Abstract: | Cognition deficit is one of the most common symptoms of schizophrenia, including abstractthinking and memory, and att ention defi cits. Previous studies have suggested that the improvementof cognition is very important for the recovery of disease and social function for the patients.Recent studies indicated that two new atypical antipsychotics, blonanserin and lurasidone,are expected to improve the cognitive impairment in patients with schizophrenia. This reviewintroduces pathogenesis of cognitive impairment in schizophrenia, mechanisms of blonanserin andlurasidone in the improvement of cognitive impairment and progress in their clinical application forschizophrenia. We hope that this review could guide clinical use of antipsychotics and provide newdirections for future studies. |
| Keywords: | schizophrenia cognitive function blonanserin lurasidone |
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