| 肺癌与慢性阻塞性肺病共病的发病机制 |
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| 引用本文： | 李窕,何雪,陈燕. 肺癌与慢性阻塞性肺病共病的发病机制[J]. 中南大学学报(医学版), 2017, 42(10): 1212-1216. DOI: 10.11817/j.issn.1672-7347.2017.10.014 |
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| 作者姓名： | 李窕 何雪 陈燕 |
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| 作者单位： | 中南大学湘雅二医院呼吸内科，长沙 410011 |
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| 基金项目： | 国家自然科学基金(81270100)；湖南省科技厅重点研发计划(2015SK20403)；中南大学中央高校基本科研业务费专项资金(2016zzts551)。 |
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| 摘 要： | 肺癌和慢性阻塞性肺病都是严重威胁人类健康的疾病，给社会带来了沉重的经济学负担。流行病学调查显示肺癌和慢性阻塞性肺病具有高共病率。吸烟是二者共同的危险因素，其可能通过某些共同的通路引起疾病的发生。肺癌和慢性阻塞性肺病的共同发病机制涉及肺部早衰、氧化应激和炎症、端粒长短、基因易感性及表观遗传学。
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| 关 键 词： | 肺癌 慢性阻塞性肺病 吸烟 氧化应激 |
Mechanism of lung cancer and chronic obstructivepulmonary disease |
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| LI Tiao,HE Xue,CHEN Yan. Mechanism of lung cancer and chronic obstructivepulmonary disease[J]. Journal of Central South University. Medical sciences, 2017, 42(10): 1212-1216. DOI: 10.11817/j.issn.1672-7347.2017.10.014 |
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| Authors: | LI Tiao HE Xue CHEN Yan |
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| Affiliation: | Department of Respiratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China |
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| Abstract: | Lung cancer and chronic obstructive pulmonary disease (COPD) are both serious threats to humanhealth, resulting in a heavy economic burden for the society. Epidemiological studies have shownthat lung cancer and COPD have a high comorbid rate. Cigarette smoking is a congenerous riskfactor for both lung cancer and COPD, and may lead to these diseases by triggering certain similarpathways. The common pathogenesis of lung cancer and chronic obstructive pulmonary diseaseinvolves premature pulmonary failure, oxidative stress and infl ammation, telomere length, geneticsusceptibility, and epigenetics. |
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| Keywords: | lung cancer chronic obstructive pulmonary disease cigarett e smoking oxidative stress |
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