多囊卵巢综合征患者血清betatrophin水平升高及其影响因素

目的：探讨多囊卵巢综合征患者血清betatrophin水平及其影响因素。方法：收集多囊卵巢综合征患者100例为多囊卵巢综合征组(PCOS组)，另收集年龄匹配的健康妇女40例作为健康对照组(NC组)。检测受试者基本临床及实验室指标，并采用酶联免疫吸附法测定betatrophin水平，采用SPSS19.0分析数据。结果：PCOS组血清betatrophin高于NC组(P<0.05)。 PCOS组血清betatrophin水平和年龄、总体胰岛素敏感性指数正相关，与体质量指数、空腹胰岛素、胰岛素抵抗指数、β细胞功能指数负相关，经多重线性逐步回归分析，年龄及腰臀比是血清betatrophin的独立影响因素；NC组无此相关性。高betatrophin浓度受试者发生多囊卵巢综合征的概率更高。结论：多囊卵巢综合征患者血清betatrophin水平升高，但与胰岛素抵抗未见相关，年龄及腰臀比是其独立影响因素。

Elevated serum levels of betatrophin in patients with polycystic ovary syndrome and the influential factors

Objective: To determine serum levels of betatrophin in patients with polycystic ovary syndrome (PCOS) and the influential factors. Methods: A total of 100 PCOS patients were enrolled randomly as a PCOS group, and 40 age-matched healthy women were recruited as a normal control (NC) group. Primary clinical or biochemical parameters of the subjects were detected. The results were analyzed by SPSS 19.0. Results: Serum betatrophin levels were elevated in the PCOS group compared with the NC group. Serum betatrophin levels were positively correlated with age and Whole Body Insulin Sensitivity Index (WBISI),and negatively correlated with body mass index, fasting insulin(FINS), homeostatic model assessment insulin resistance (HOMA-IR) and homeostatic model assessment β cell function (HOMA-β). Multiple linear stepwise regression analysis showed that age and waist hip ratio (WHR) were independent influential factors for the level of betatrophin. PCOS was more likely to occur in women with higher betatrophin levels. Conclusion: Serum betatrophin levels increase in women with PCOS and they are independently associated with age and WHR. There is no significant correlation between betatrophin and insulin resistance or insulin levels.