中药有效成分抗宫颈癌作用机制的研究进展

宫颈癌是威胁女性健康的第二大癌症,因其极高的死亡率而备受国内外研究者的关注。目前,大多采用放射性治疗及化学药物治疗癌症的副作用较大,而中药有效成分在抗肿瘤方面有着多途径、多环节、多靶点、毒副作用小等优势,已成为抗癌药物的重点研发对象。近年来,相关科研人员对中药有效成分作用于人宫颈癌细胞的体外抑制活性及作用机制研究尤为活跃。文章拟从中药提取物、多糖、生物碱、皂苷、黄酮类、萜类、醌类、挥发油、酯类、酚类、砷剂类、蛋白组分等中药有效成分为出发点,以抗宫颈癌作用机制即抑制细胞增殖,诱导癌细胞凋亡;抑制细胞侵袭、迁移及黏着斑激酶(FAK)磷酸化;抑制血管内皮生长因子(VEGF)过表达;干扰细胞有丝分裂;抑制端粒酶活性;调节细胞信号通路;下调HPV E6基因表达;调节机体免疫能力为主要内容,对宫颈癌细胞的体外抑制活性与作用机制进行综述,以期为抗宫颈癌药物的研发与利用提供理论参考。

Research progress in mechanism of traditional Chinese medicine active ingredients against cervical cancer

Cervical cancer is the second cancer that threatens women's health, and has attracted the attention of researchers at home and abroad because of its extremely high mortality rate. At present, most of the radiotherapy methods and chemical drugs for cancer treatment have serious side effects, and the active ingredients of traditional Chinese medicine have become the key research and development targets of anti-cancer drugs due to many advantages, such as multi-channel, multi-link, multi-target, and less toxicity. In recent years, researchers have been particularly active in researching the inhibitory activity and mechanism of active ingredients of traditional Chinese medicine for human cervical cancer cells. In this paper, the inhibitory activity and mechanism of traditional Chinese medicine against human cervical cancer cells were investigated from crude extract of traditional Chinese medicine, polysaccharides, alkaloids ,saponins, flavonoids, terpenoids, quinones, volatile oils, esters, phenols, arsenical, protein components as the starting point;anti-cervical cancer mechanism was investigated, such as inhibiting cell proliferation inducing apoptosis of cancer cells, inhibiting cell invasion, migration and focal adhesion kinase( FAK) phosphorylation, inhibiting vascular endothelial growth factor (VEGF) over-expression interfering with cell mitosis, inhibiting Granzvme activity, regulating cellular signaling pathway, down-regulating HPV E6 gene expression, and regulating immune function. Its in vitro inhibitory activity and mechanism of action on cervical cancer cells were reviewed, in order to provide a theoretical basis for the development and utilization of anti-cervical cancer drugs.