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Analysis of the relationship between pregnancy dyslipidemia and fetal congenital heart disease

??Objective To investigate the relationship between the presence of dyslipidemia in pregnant females and the risk of congenital heart defects??CHD??. Methods A total of 54 pregnant females at 24 to 28 weeks??w?? of gestation admitted between March 2013 and June 2014 in Department of Pediatric Cardiology??First Affiliated Hospital of SUN Yat-sen University were enrolled in the study . The case group included 18 females who had a fetus with cardiac defects??and each case was matched with 2 controls with no pregnancy complications. The mean ages were 29.06??SD=3.11?? years and 29.03??SD=3.9?? years in the case and control groups??respectively. The main outcome measurements were total cholesterol??TC????triglycerides??TG????low-density lipoprotein cholesterol??LDL-c????high-density lipoprotein cholesterol??HDL-c????apolipoprotein and homocysteine. Results Patients in the case group had a significantly higher mean LDL-c??4.15 mmol/L vs. 3.45 mmol/L?? and apolipoprotein B ??2.23 g/L vs. 1.78 g/L????all P??0.05?? than those in the control group. Correlation analysis indicated that LDL-C??r=0.32??P=0.017????apolipoprotein B??r=0.33??P=0.016?? and homocysteine??r=0.34??P=0.011?? were associated with fetal congenital heart disease.Conclusion Serum LDL-cholesterol and apolipoprotein B levels in the case group are significantly higher than those in the control group. Pregnancy dyslipidemia may be associated with a higher incidence rate of CHD.