| Nrf2/HO-1信号轴在氧化应激性疾病中的机制 |
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| 引用本文： | 王甜甜,陈淳媛,杨雷,曾志辉,曾茂君,蒋文,刘琳,赵明一. Nrf2/HO-1信号轴在氧化应激性疾病中的机制[J]. 中南大学学报(医学版), 2019, 44(1): 74-80. DOI: 10.11817/j.issn.1672-7347.2019.01.012 |
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| 作者姓名： | 王甜甜 陈淳媛 杨雷 曾志辉 曾茂君 蒋文 刘琳 赵明一 |
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| 作者单位： | 中南大学湘雅三医院儿科,长沙410013;中南大学湘雅医学院临床医学系,长沙410013;中南大学湘雅三医院儿科,长沙,410013;广东省心血管病研究所,广东省人民医院心血管外科,广东省医学科学院,广州510080;中南大学湘雅三医院儿科,长沙410013;常德市妇幼保健院儿科,湖南常德415000 |
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| 基金项目： | 国家自然科学基金(81500231)；湖南省自然科学基金(2018JJ3786)；中南大学湘雅三医院“新湘雅人才工程”(JY201524)。 |
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| 摘 要： | 在氧化应激性疾病发生发展过程中，活性氧(reactive oxygen species，ROS)的清除障碍或生成过多导致爆发性释放后，可损伤机体各组织器官。最新研究证明：核因子E2相关因子2/血红素加氧酶-1(nuclear factor erythroid-2-related actor 2/heme oxygenase 1，Nrf2/HO-1)信号轴通过发挥抗炎、抗氧化、减少线粒体损伤、调节钙离子内流、调控细胞凋亡(apoptosis)、焦亡(pyroptosis)、铁死亡(ferroptosis)及自噬(autophagy)等作用，抵抗氧化应激损伤，这为它在不同脏器(呼吸、心血管、神经、消化、泌尿、血液)的氧化应激性疾病中的治疗潜力提供了分子机制上的理论基础。因此，有效调控Nrf2/HO-1信号轴可成为治疗氧化应激性疾病的重要靶点。
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| 关 键 词： | 核因子E2相关因子2/血红素加氧酶-1 氧化应激性疾病 机制 |
Role of Nrf2/HO-1 signal axis in the mechanisms for oxidative stress-relevant diseases |
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| WANG Tiantian,CHEN Chunyuan,YANG Lei,ZENG Zhihui,ZENG Maojun,JIANG Wen,LIU Lin,ZHAO Mingyi. Role of Nrf2/HO-1 signal axis in the mechanisms for oxidative stress-relevant diseases[J]. Journal of Central South University. Medical sciences, 2019, 44(1): 74-80. DOI: 10.11817/j.issn.1672-7347.2019.01.012 |
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| Authors: | WANG Tiantian CHEN Chunyuan YANG Lei ZENG Zhihui ZENG Maojun JIANG Wen LIU Lin ZHAO Mingyi |
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| Affiliation: | 1. Department of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013; 2. Department of Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha 410013; 3. Guangdong Cardiovascular Institute; Department of Cardiovascular Surgery, Guangdong General Hospital; Guangdong Academy of Medical Sciences, Guangzhou 510080; 4. Department of Pediatrics, Maternal and Child Health Hospital of Changde City, Changde Hunan 415000, China |
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| Abstract: | In the development of oxidative stress-relevant diseases, reactive oxygen species (ROS) removal obstacle or excess production results in the damage of the body tissues and organs. Recent studies have demonstrated that nuclear factor E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) axis played a significant role in anti-oxidative stress. The Nrf2/HO-1 axis counteracts oxidative stress injury by its resistance to inflammation, oxidation, mitochondrial damage and calcium influx, apoptosis, pyroptosis, ferroptosis and autophagy, which provides a theoretical basis for its therapeutic effect on various oxidative stress-relevant diseases in multiple organs (respiratory, cardiovascular, nervous, digestive, urinary and blood systems). Therefore, effective regulation of the Nrf2/HO-1 signal axis can be an important strategy for treatment of oxidative stress-relevant diseases. |
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| Keywords: | nuclear factor erythroid-2-related factor 2/heme oxygenase-1 oxidative stress diseases mechanism |
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