脑血管血流动力学积分值与亚临床动脉硬化指标的相关性

目的：探讨脑血管血流动力学指标(cerebrovascular hemodynamic index，CVHI)积分值与亚临床动脉硬化指 标的相关性。方法：以中南大学湘雅三医院健康管理中心的27 184名体检人群为研究对象，采用线性回归分析CVHI 积分值、改良版弗莱明翰评分量表(framingham stroke profile，FSP)和国人心脑血管缺血疾病(ischemic cardiovascular diseases，ICVD)量表的相关性；对其中11 580名受检对象采用多因素logistic回归模型进行CVHI积分值与臂踝脉搏波 传导速度(brachial ankle pulse wave velocity，baPWV)、颈动脉斑块及颈动脉内膜中层厚度(carotid intima-media thickness， CIMT)的相关性分析；对其中9 860名受检对象采用多因素logistic回归模型进行CVHI积分值与尿微量白蛋白及胱抑素 C的相关性分析。结果：本研究中CVHI积分值<75分的人数占总体检人数的12.98%；CVHI积分值与改良版FSP分值呈 负相关(r=–0.484，P<0.01)，与ICVD量表分值亦呈负相关(r=–0.455，P<0.01)；多因素logistic回归模型发现baPWV，颈 动脉斑块，尿微量白蛋白及胱抑素C是CVHI积分值的独立影响因素。结论：CVHI积分值与改良版FSP和ICVD量表、 亚临床动脉硬化相关指标(baPWV，颈动脉斑块，尿微量白蛋白及胱抑素C)均具有良好的相关性，推荐将其作为脑卒 中零级预防和一级预防的筛查手段。

Correlation between cerebrovascular hemodynamic index accumulative score and subclinical arteriosclerosis indicators

Objective: To explore the correlation between cerebrovascular hemodynamic index (CVHI) accumulative score and subclinical arteriosclerosis indicators. Methods: A total of 27 184 cases were collected from the Health Management Center, the Th ird Xiangya Hospital, Central South University. Linear regression analysis was carried out to confi rm the correlations between CVHI accumulative score and the modifi ed Framingham stroke profi le (FSP), as well as between CVHI accumulative score and cerebrovascular diseases (ICVD) scale. The correlation between CVHI accumulative score and brachial-ankle pulse wave velocity (baPWV), carotid plaque orcarotid intima-media thickness (CIMT) was analyzed by multifactor logistic regression model in 11 580 cases. Moreover, the correlation between CVHI accumulative score and microalbuminuria or serum cystatin C was performed by multifactor logistic regression model in 9 860 cases. Results: In this study, the people whose CVHI accumulative score was less than 75 accounted for 12.98%. The CVHI accumulative score was negatively related with the modified FSP score (r=–0.484, P<0.01) or ICVD score (r=–0.455, P<0.01). The multifactor logistic regression model found that the baPWV, carotid plaque, microalbuminuria and serum cystatin C were independent predictors for CVHI accumulative score. Conclusion: The CVHI accumulative score is correlated with the modified FSP score, ICVD score and indexes of subclinical arteriosclerosis (baPWV, carotid plaque, microalbuminuria and serum cystatin C). The CVHI accumulative score could be used as a tool for zero-level and primary prevention of cerebral stroke.