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Study on the relationship between neonatal respiratory distress syndrome and SP-B gene exon 7 in the Han nationality and the Mongol nationality in Inner Mongolia

??Objective To investigate the characteristics of SP-B gene exon 7 mutation of neonatal respiratory distress syndrome??NRDS?? in the Han nationality and the Mongol nationality. Methods The prospective study method was used. Eighty-five infants with NRDS??the NRDS group?? and eighty-four infants without NRDS??the control group?? were selected as the research objects in June 2013- June 2015 in Inner Mongolia Medical University-Affiliated Hospital. In these cases?? there were 55 cases with RDS??the NRDS group?? and 58 cases without RDS??the control group?? in the han nationality?? in the Mongol nationality there were 30 cases with RDS??the NRDS group?? and 26 cases without RDS??the control group??. We extracted DNA and PCR gene analysis was used to detect candidate genes on exon 7 of SP-B. Results Between the NRDS group and the control group of children?? gender?? gestational age?? birth weight?? birth way and whether to promote lung mature regularly had no significant correlation ??P??0.05??. Gene mutations were not found on exon 7 of SP-B in these two groups. Conclusion There is no mutation on SP-B gene exon 7 in this study.There is no difference on SP-B gene exon 7 between the Mongolian and the Han nationality in the Inner Mongolia area.