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脑积水发病机制的研究进展
引用本文:詹潮鸿,张向阳,肖格磊. 脑积水发病机制的研究进展[J]. 中南大学学报(医学版), 2019, 44(10): 1188-1195. DOI: 10.11817/j.issn.1672-7347.2019.180662
作者姓名:詹潮鸿  张向阳  肖格磊
作者单位:中南大学湘雅医院神经外科,脑积水诊疗中心,长沙 410008;中南大学湘雅医院神经外科,脑积水诊疗中心,长沙 410008;中南大学湘雅医院神经外科,脑积水诊疗中心,长沙 410008
基金项目:湖南省自然科学基金(2019JJ50949);湖南省卫生健康委员会科研项目(B2019187)。
摘    要:脑积水是一种常见但病因复杂的神经系统疾病,以脑脊液在脑室系统及蛛网膜下腔内聚积并不断增长为特征,既可由先天性遗传因素导致,也可由后天脑外伤、脑出血等疾病诱发。脑脊液的产生与被吸收进入静脉窦的不平衡、脑脊液循环通路受阻或者脑室内渗透压维持功能紊乱均能导致脑脊液增多、脑室扩张。

关 键 词:脑积水  发病机制  循环理论  渗透理论

Advances in research on the pathogenesis of hydrocephalus
ZHAN Chaohong,ZHANG Xiangyang,XIAO Gelei. Advances in research on the pathogenesis of hydrocephalus[J]. Journal of Central South University. Medical sciences, 2019, 44(10): 1188-1195. DOI: 10.11817/j.issn.1672-7347.2019.180662
Authors:ZHAN Chaohong  ZHANG Xiangyang  XIAO Gelei
Affiliation:Department of Neurosurgery, Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha 410008, China
Abstract:Hydrocephalus is a common neurological disease with complex etiology. It is characterized bythe accumulation and continuous growth of cerebrospinal fluid in the ventricular system andsubarachnoid space. Hydrocephalus can be caused by congenital genetic factors, brain trauma andcerebral hemorrhage. Th rough the eff orts of many researchers, the pathogenesis of hydrocephalusis being completed, but it has not been fully explained. The imbalance of cerebrospinal fluidproduction and absorption into the sinus, and disorder of the cerebrospinal fluid circulationpathway or the osmotic pressure maintenance in the ventricle can lead to increased cerebrospinalfl uid and ventricular dilatation.
Keywords:hydrocephalus  pathogenesis  circulation theory  osmotic pressure theory  
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