| 前列腺癌的去势抵抗机制 |
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| 引用本文： | 陈放知,赵晓昆.前列腺癌的去势抵抗机制[J].中南大学学报(医学版),2017,42(10):1217-1221. |
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| 作者姓名： | 陈放知 赵晓昆 |
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| 作者单位： | 中南大学湘雅二医院泌尿外科，长沙 410011 |
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| 摘 要： | 前列腺癌是男性最常见的泌尿生殖系统的恶性肿瘤，去势治疗后肿瘤细胞常呈现去势抵抗特性。雄激素
受体变异、再活化及肿瘤微环境改变等是前列腺癌进展成为去势抵抗性前列腺癌(castration-resistant prostate carcinoma，
CRPC)的主要病理因素。系统性分析和理解前列腺癌的去势抵抗机制是构建CRPC的精准治疗策略的基础。
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| 关 键 词： | 前列腺癌 去势抵抗 雄激素受体再活化 肿瘤微环境 |
Mechanisms for castration-resistance of prostate carcinoma |
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| CHEN Fangzhi,ZHAO Xiaokun.Mechanisms for castration-resistance of prostate carcinoma[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2017,42(10):1217-1221. |
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| Authors: | CHEN Fangzhi ZHAO Xiaokun |
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| Institution: | Department of Urology, Second Xiangya Hospital, Central South University, Changsha 410011, China |
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| Abstract: | Prostate cancer is the most prevalent male urogenital malignancy. The tumor cells are prone to
castration-resistance after androgen deprivation therapy. Variation and reactivation of androgen
receptor, and the change in the tumor microenvironment are the major pathological factors for
development of castration-resistant prostate carcinoma (CRPC). Systematically analyzing and
understanding the mechanisms for castration-resistance of prostate carcinoma will be signifi cant for
laying the basis for improvement of the strategies on precise treatment for CRPC. |
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| Keywords: | prostate cancer castration-resistance androgen receptor reactivation tumor microenvironment |
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