| 非酒精性脂肪肝病中长链非编码 RNA的表达谱 |
| |
| 引用本文： | 孙传政,黄飞舟,严文广,刘怀政,汪长发. 非酒精性脂肪肝病中长链非编码 RNA的表达谱[J]. 中南大学学报(医学版), 2017, 42(7): 741-748. DOI: 10.11817/j.issn.1672-7347.2017.07.001 |
| |
| 作者姓名： | 孙传政 黄飞舟 严文广 刘怀政 汪长发 |
| |
| 作者单位： | 中南大学湘雅三医院 1. 急诊科；2. 肝胆外科；3. 康复科，长沙 410013 |
| |
| 基金项目： | 国家自然科学基金(81600461)。 |
| |
| 摘 要： | 目的：分析非酒精性脂肪肝病(non-alcoholic fatt y liver disease，NAFLD)中长链非编码RNA(lncRNA)的表达谱特征。方法：采用lncRNA-mRNA基因芯片检测单纯性胆囊结石伴或不伴NAFLD患者的肝组织样本，获得lncRNA差异性表达谱。进一步使用生物信息学技术对差异表达的基因予以分析。结果：与正常样本相比，NAFLD肝样本内共有1 735个lncRNAs和1 485个mRNAs异常表达，其中535个lncRNAs和760个mRNAs上调，1 200个lncRNAs和725个mRNAs下调。结论：与正常肝组织相比，NAFLD组织中lncRNA表达谱明显异常，这些lncRNAs可能在NAFLD的发生和发展中发挥重要作用。
|
| 关 键 词： | 长链非编码RNA 非酒精性脂肪肝病 表达谱 基因芯片 |
Expression profile of long non-coding RNA in#br#non-alcoholic fatty liver disease |
| |
| SUN Chuanzheng,HUANG Feizhou,YAN Wenguang,LIU Huaizheng,WANG Changfa. Expression profile of long non-coding RNA in#br#non-alcoholic fatty liver disease[J]. Journal of Central South University. Medical sciences, 2017, 42(7): 741-748. DOI: 10.11817/j.issn.1672-7347.2017.07.001 |
| |
| Authors: | SUN Chuanzheng HUANG Feizhou YAN Wenguang LIU Huaizheng WANG Changfa |
| |
| Affiliation: | 1. Emergency Department; 2. Department of Hepatic Surgery; 3. Department of Rehabilition,
Th ird Xiangya Hospital, Central South University, Changsha 410013, China |
| |
| Abstract: | Objective: To analyze the characteristics of long non-coding RNA (lncRNA) expression in nonalcoholicfatt y liver disease (NAFLD).Methods: lncRNA-mRNA microarray was conducted on the liver tissue samples from 10 patientswith simple gallbladder stone (5 NAFLD liver samples and 5 normal liver samples), and thediff erentially expressed lncRNA was analyzed by bioinformatics technology.Results: Compared with the normal liver samples, there were abnormal expression of 1 735lncRNAs and 1 485 mRNAs in NAFLD liver samples. Among them, 535 lncRNAs and 760mRNAs were up-regulated, 1 200 lncRNAs and 725 mRNAs were down-regulated.Conclusion: Compared with normal liver, the expression of lncRNA in NAFLD tissues is obviouslyabnormal. Th ese lncRNAs may play an important role in the occurrence and development of NAFLD. |
| |
| Keywords: | long non-coding RNA non-alcoholic fatty liver disease expression profile gene chip |
|
| 点击此处可从《中南大学学报(医学版)》浏览原始摘要信息 |
|
点击此处可从《中南大学学报(医学版)》下载全文 |
