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当归拈痛汤合宣痹汤加减治疗湿热蕴结型急性痛风性关节炎的临床观察
引用本文:李雯,戴晓云,柯新桥. 当归拈痛汤合宣痹汤加减治疗湿热蕴结型急性痛风性关节炎的临床观察[J]. 中国实验方剂学杂志, 2020, 26(14): 117-122
作者姓名:李雯  戴晓云  柯新桥
作者单位:深圳市龙华区中心医院,广东 深圳 518110
基金项目:深圳市科技计划项目(JCYJ20170307160524377)
摘    要:目的:探讨当归拈痛汤合宣痹汤加减治疗湿热蕴结型急性痛风性关节炎的临床疗效及对患者血清白细胞介素-1β(IL-1β),白细胞介素-6(IL-6),白细胞介素-8(IL-8),肿瘤坏死因子-α(TNF-α)的影响。方法:将126例湿热蕴结型急性痛风性关节炎患者随机分为观察组、对照组,各63例。在非药物治疗的基础上,对照组、观察组分别使用西药常规治疗、当归拈痛汤合宣痹汤加减治疗1周,观察两组的临床疗效和治疗前后IL-1β,IL-6,IL-8,TNF-α水平。结果:对照组临床疗效总有效率为79.37%(50/63),观察组总有效率为95.24%(60/63),观察组高于对照组(P<0.05)。两组的治疗后疼痛、关节压痛、关节红肿、活动受限评分均较治疗前下降(P<0.01),治疗后观察组的上述主要症状、体征评分均低于对照组(P<0.05)。治疗后两组血尿酸(UA),血沉(ESR),超敏C反应蛋白(hs-CRP)水平均显著下降(P<0.01),且治疗后观察组的上述指标水平均低于对照组(P<0.05)。治疗后两组IL-1β,IL-6,IL-8,TNF-α水平均显著下降(P<0.01),且治疗后观察组上述指标水平均低于对照组(P<0.05)。结论:与西药常规治疗比较,当归拈痛汤合宣痹汤加减治疗湿热蕴结型急性痛风性关节炎的疗效更优,并且更有效地降低IL-1β,IL-6,IL-8,TNF-α水平。

关 键 词:当归拈痛汤  宣痹汤  急性痛风性关节炎  湿热蕴结型  炎症因子

Clinical Efficacy of Modified Danggui Niantongtang Combined with Xuanbitang in Treating Damp-heat Type Acute Gouty Arthritis
LI Wen,DAI Xiao-yun,KE Xin-qiao. Clinical Efficacy of Modified Danggui Niantongtang Combined with Xuanbitang in Treating Damp-heat Type Acute Gouty Arthritis[J]. China Journal of Experimental Traditional Medical Formulae, 2020, 26(14): 117-122
Authors:LI Wen  DAI Xiao-yun  KE Xin-qiao
Affiliation:Shenzhen Longhua District Central Hospital, Shenzhen 518110, China
Abstract:Objective:To observe the clinical efficacy of modified Danggui Niantongtang combined with Xuanbitang in treating damp-heat type acute gouty arthritis,and investigate its effect on levels of interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α).Method:Totally 126 patients were randomly divided into control group and observation group,with 63 cases in each group.In addition to non-medication treatment,patients in control group were given conventional western medicine treatment for 1 week,while patients in observation group were given modified Danggui Niantongtang combined with Xuanbitang for 1 week.The levels of IL-1β,IL-6,IL-8,TNF-αbefore and after treatment were observed.Result:The total effective rate was 79.37%in control group and 95.24%in observation group,with significant differences(P<0.05).After treatment,the scores of arthralgia,tenderness,swelling,activity restriction in both groups were significantly decreased(P<0.01),and those in observation group were lower than those in control group(P<0.05).The levels of uric acid(UA),high-sensitivity C-reactive protein(hs-CRP),erythrocyte sedimentation rate(ESR)were significantly decreased(P<0.01)after treatment,and those in observation group were lower than those in the control group(P<0.05).The levels of IL-1β,IL-6,IL-8,TNF-αwere significantly decreased(P<0.01)after treatment,and those in the observation group were lower than those in the control group(P<0.05).Conclusion:Compared with conventional western medicine treatment,modified Danggui Niantongtang combined with Xuanbitang has a better efficacy in treating dampheat type acute gouty arthritis and reducing levels of IL-1β,IL-6,IL-8,TNF-α.
Keywords:Danggui Niantongtang  Xuanbitang  acute gouty arthritis  damp-heat type  inflammatory factor
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