| 慢性阻塞性肺疾病动物模型的研究进展 |
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| 引用本文： | 李丽球,谢丽华,孙圣华.慢性阻塞性肺疾病动物模型的研究进展[J].中南大学学报(医学版),2017,42(9):1105-1110. |
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| 作者姓名： | 李丽球 谢丽华 孙圣华 |
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| 作者单位： | 中南大学湘雅三医院呼吸内科，长沙 410013 |
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| 基金项目： | 国家自然科学基金青年基金(81500033)。 |
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| 摘 要： | 慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)是一种可以预防和治疗的不完全可逆性慢
性气道疾病，其发病率和致死率均较高，并且呈逐年上升趋势。建立COPD动物模型是探索其发病机制的重要方法之
一，目前缺乏统一标准的COPD动物模型构建方法，动物物种选择、模型制备及模型评估作为该模型构建的关键点在
不断更新。
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| 关 键 词： | 慢性阻塞性肺疾病 疾病动物模型 机制 |
Progress in study on animal models of
chronic obstructive pulmonary disease |
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| LI Liqiu,XIE Lihua,SUN Shenghua.Progress in study on animal models of
chronic obstructive pulmonary disease[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2017,42(9):1105-1110. |
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| Authors: | LI Liqiu XIE Lihua SUN Shenghua |
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| Institution: | Department of Respiratory Medicine, Th ird Xiangya Hospital, Central South University, Changsha 410013, China |
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| Abstract: | Chronic obstructive pulmonary disease (COPD) is an incompletely reversible chronic airway
disease that can be prevented and cured. Th ere is a tendency toward increasing the morbidity and
mortality for COPD. Establishment of an animal model for COPD is an important step to explore
the pathogenesis of this disease. Presently, a well-recognized COPD animal model is not available.
The key points for establishing the COPD animal models, such as selection of animal species,
parameters for model evaluation, are constantly updated. |
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| Keywords: | chronic obstructive pulmonary disease animal models mechanism |
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