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| TRPM7与肿瘤 | |
| 引用本文： | 赵敏,罗晨辉,王瑛,王静. TRPM7与肿瘤[J]. 中南大学学报(医学版), 2016, 41(3): 333-336. DOI: 10.11817/j.issn.1672-7347.2016.03.017 |
| 作者姓名： | 赵敏 罗晨辉 王瑛 王静 |
| 作者单位： | 1. 中南大学湘雅医院临床药理研究所，长沙 410008；2. 中南大学临床药理研究所，遗传药理学湖南省重点实验室， 长沙410078；3. 湖南省肿瘤医院，长沙 410013 |
| 基金项目： | 湖南省自然科学基金(2015JJ2093)。 |
| 摘 要： | 瞬时受体电位(transient receptor potential，TRP)通道是位于细胞膜上的一类重要的阳离子通道超家族。TRPM(transient receptor potential melastatin)7是TRPM亚族的一员，是具有离子通道和激酶活性双功能的膜蛋白。它对阳离子有通透性，使细胞去极化，可使自身和底物磷酸化。TRPM7可以介导感觉信号的传递，调节细胞钙镁平衡和影响发育，其表达及活性异常与多种疾病特别是肿瘤的发生具有相关性。TRPM7通道激酶在细胞的增殖、存活、分化、生长和迁移等一系列细胞活动中起重要作用。 |
| 关 键 词： | 瞬时受体电位通道 TRPM7 恶性肿瘤 |
TRPM7 and tumor |
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| ZHAO Min,LUO Chenhui,WANG Ying,WANG Jing. TRPM7 and tumor[J]. Journal of Central South University. Medical sciences, 2016, 41(3): 333-336. DOI: 10.11817/j.issn.1672-7347.2016.03.017 | |
| Authors: | ZHAO Min LUO Chenhui WANG Ying WANG Jing |
| Affiliation: | 1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008; 2. Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078; 3. Hunan Cancer Hospital, Changsha 410013, China |
| Abstract: | The transient receptor potential (TRP) family is a superfamily of cation channels located on the cell membrane. Transient receptor potential melastatin (TRPM) 7, a member of the TRPM subgroup of TRP channels, and was the most representative biofunctional membrane protein. It conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. It is capable of phosphorylating TRPM7 and other substrates. TRPM7 can mediate sensory transmission, regulate cellular Ca2+ and Mg2+ homeostasis and affect embryonic development. Abnormal expression and/or activity of the TRPM7 channel kinase is involved in a variety of diseases, particularly the development and progression of cancer. TRPM7 channel-kinase is essential for cellular processes, such as proliferation, survival, differentiation, growth, and migration. |
| Keywords: | transient receptor potential channels TRPM7 malignant tumors |
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