| miR-93与肿瘤的研究进展 |
| |
| 引用本文： | 刘更[综述] 周鸿鹰[审校]. miR-93与肿瘤的研究进展[J]. 四川解剖学杂志, 2013, 0(3): 28-31 |
| |
| 作者姓名： | 刘更[综述] 周鸿鹰[审校] |
| |
| 作者单位： | 四川大学华西基础医学与法医学院,成都610041 |
| |
| 摘 要： | 研究表明microRNA与肿瘤的发生发展有着密切关系。其中，miR-93的差异表达在肿瘤细胞的增殖、凋亡、迁移、分化等方面发挥了重要作用。miR-93通过靶向调节PTEN、E2F1、Sixl等基因的表达促进肿瘤增殖，抑制细胞凋亡，增强肿瘤耐药；通过调节Smad7基因诱导肿瘤细胞发生上皮一间质转换，是一个潜在的癌基因。
|
| 关 键 词： | miR-93 肿瘤 |
Research Advancement of miR-93 and Cancer |
| |
| Affiliation: | Liu Geng Zhou Hongying (West China School of Preclinical and Forensic Medicine, Sichuan University, Cheng du 610041 ,China} |
| |
| Abstract: | It has been revealed that mieroRNA （miRNA） expression contribute to the initiation and progression of cancer. Among them,deregulated expression of miR-93 play critical roles in cell proliferation,apoptosis,migration and differentiation, miR-93 may promote potential proliferative,anti-apoptotie and drug-resistance effects via binding to PTEN,E2F1, Six1 and any other genes, miR-93 can additionally target the inhibitory Smad7 to induce EMT, which may be a potential oncogene. |
| |
| Keywords: | miR-93 Cancer |
| 本文献已被 维普 等数据库收录！ |
|
