抗-CCP抗体、RF与CRP联合检测对类风湿性关节炎早期诊断研究

目的探讨抗环瓜氨酸多肽（抗-CCP）抗体、类风湿因子（RF）与C-反应蛋白（CRP）联合检测在类风湿性关节炎（RA）中的诊断价值。方法采用半定量酶联免疫吸附法和定量免疫散色比浊法分别检测两组人群血清中的抗一CCP抗体、RF与C一反应蛋白（CRP）浓度，并分析上述三指标与RA的相关性。结果抗-CCP抗体诊断RA的特异度为93．5％，灵敏度为72．6％，RF为77．3％和83．4％，CRP为63．6％和82．3％，三者诊断灵敏度和特异度分别高达92．5％和97．6Voo。结论抗-CCP抗体诊断RA的特异度最高，RF的灵敏度最高，而三者联合早期诊断RA效率最好，与单一诊断指标相比具有明显的统计学意义。

Early Diagnosis Value of Anti-CCP antibody, Rheumatoid Factor and C-reactive Protein in Rheumatoid Arthritis

Objective The aim of this study was to explore the early diagnosis value of anti-CCP antibody, rheuma- toid factor and C-reactive protein in Rheumatoid Arthritis （RA）. Methods The serum anti-CCP antibody was detec- ted by semi-quantitative immunosorbent （ELISA） and CRP as well as RF concentrations were detected by immune turbidimetry bulk color. Results The RA diagnostic specificity and sensitivity of the anti-CCP antibody, RF and CRP as well as the combination of three diagnostic markers were 93.5% and 72.6%, 77. 3% and 77.3%, 63. 6% and 82.3%,92.5% and 97.6%, respectively. Conclusion The RA highest diagnostic specificity of three markers was anti-CCP antibody and the highest diagnostic sensitivity was RF. The best diagnostic efficiency of RA was com- bination detection of the three markers, which had statistical significance, compared with a single diagnostic marker.