Colforsin-induced vasodilation in chronic hypoxic pulmonary hypertension in rats |
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| Authors: | Ayumu Yokochi Hiroo Itoh Junko Maruyama Erquan Zhang Baohua Jiang Yoshihide Mitani Chikuma Hamada Kazuo Maruyama |
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| Institution: | (1) Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, University of Mie, 2-174 Edobashi, Tsu Mie, 514-8507, Japan;(2) Department of Physiology, Faculty of Medicine, University of Mie, 2-174 Edobashi, Tsu Mie, 514-8507, Japan;(3) Department of Pediatrics, Faculty of Medicine, University of Mie, 2-174 Edobashi, Tsu Mie, 514-8507, Japan;(4) Department of Internal Medicine, Nabari City Hospital, 178 Yurigaoka-Nishi-1ban-cho, Nabari Mie, 518-0481, Japan;(5) Faculty of Engineering, Tokyo University of Science, 1-14-6 Kudankita, Chiyoda-ku, Tokyo 102-0073, Japan |
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| Abstract: | Purpose Colforsin, a water-soluble forskolin derivative, directly activates adenylate cyclase and thereby increases the 3′,5′-cyclic
adenosine monophosphate (cAMP) level in vascular smooth muscle cells. In this study, we investigated the vasodilatory action
of colforsin on structurally remodeled pulmonary arteries from rats with pulmonary hypertension (PH). |
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