Blockade effect of mu and kappa opioid antagonists on the anti-nociception induced by intra-periaqueductal grey injection of oxytocin in rats |
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Authors: | Ge Yuan Lundeberg Thomas Yu Long-Chuan |
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Institution: | Department of Physiology, College of Life Sciences, and Center for Brain and Cognitive Science, Peking University, Beijing 100871, People's Republic of China. |
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Abstract: | Intra-periaqueductal grey (PAG) injection of 1 nmol of oxytocin induced significant increases in hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats. The anti-nociceptive effect of oxytocin was attenuated significantly by subsequent intra-PAG injection of the mu opioid antagonist beta-funaltrexamine (beta-FNA) and the kappa opioid antagonist nor-binaltorphimine (nor-BNI), but not by the delta antagonist naltrindole. The results demonstrated that mu and kappa opioid receptors, not delta receptors, were involved in the oxytocin-induced anti-nociception in PAG of rats. |
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Keywords: | Hindpaw withdrawal latency Periaqueductal grey Oxytocin Mu opioid receptor Kappa opioid receptor Anti-nociception |
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