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对1例白介素11致毛细血管渗漏综合征患者的药学监护
引用本文:沈丽蓉,王凯峰.对1例白介素11致毛细血管渗漏综合征患者的药学监护[J].中国药物应用与监测,2010,7(6):364-365.
作者姓名:沈丽蓉  王凯峰
作者单位:[1]浙江大学医学院附属邵逸夫医院药剂科,浙江杭州310016 [2]浙江大学医学院附属邵逸夫医院肿瘤内科,浙江杭州310016
摘    要:1例44a男性患者,因肝癌局部复发,为行经皮肝动脉灌注栓塞术(TACE)治疗入院。入院后查血常规,PLT48×109·L-1,考虑在血小板减少的情况下TACE治疗存在出血风险,先予白介素11升血小板。白介素11治疗第2天患者出现毛细血管渗漏综合征,临床药师及时诊断,并提出治疗建议:停用白介素11,羟乙基淀粉增加胶体渗透压,地塞米松改善毛细血管通透性。治疗后,患者症状完全缓解出院。

关 键 词:白介素11  毛细血管渗漏综合征  临床药师  药学监护

Pharmaceutical care on a patient with capillary leak syndrome resulting from interleukin-11
Authors:SHEN Li-rong  WANG Kai-feng
Institution:1.Department of Pharmacy,Sir Run Run Shaw Hospital Affiliated to Medical School of Zhejiang University,Hangzhou 310016,China;2.Department of Medical Oncology,Sir Run Run Shaw Hospital Affiliated to Medical School of Zhejiang University,Hangzhou 310016,China)
Abstract:A 44-year-old man with recurrence of primary liver cancer was hospitalized for percutaneous transcatheter hepatic artery embolization(TACE).The routine blood examination showed a PLT count of 48×109·L-1.Considering the risk of bleeding in the patient with thrombocytopenia for TACE,interleukin-11 therapy was given.At the second day after interleukin-11 treatment,the patient developed capillary leak syndrome(CLS).Clinical pharmacist found this adverse drug reaction in time,and provided therapeutic recommendations as follows:discontinuing interleukin-11,using hydroxyethyl starch for increasing colloid osmotic pressure and dexamethasone for improving capillary permeability.The patient gradually recovered and discharged from hospital over 10 days.
Keywords:Interleukin-11  Capillary leak syndrome  Clinical pharmacist  Pharmaceutical care
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