奥氮平与阿立哌唑治疗精神分裂症对照研究

目的:比较奥氮平与阿立哌唑治疗精神分裂症的疗效与安全性。方法:100例精神分裂症患者随机分为两组,每组各50例。分别给予奥氮平和阿立哌唑治疗,疗程8周。采用阳性与阴性症状量表(PANSS)、临床疗效总评量表疾病严重程度(CGI-SI)、治疗中出现的症状量表(TESS)评定疗效及不良反应。结果:两组PANSS总分及CGI-SI评分均较治疗前显著下降(P均<0.01)。奥氮平组显效率76.0%,阿立哌唑组显效率72.0%,两组疗效相仿(P>0.05)。奥氮平组嗜睡、体质量增加、血脂升高的不良反应均明显高于阿立哌唑组(P<0.01);阿立哌唑组锥体外系反应、失眠、兴奋或激越均明显高于奥氮平组(P<0.01)。结论:奥氮平和阿立哌唑对精神分裂症的疗效相当,安全性较高。

A comparative study of olanzapine and aripiprazole in treatment of schizophrenia

Objective: To compare the efficacy and safety of olanzapine and aripiprazole in the treatment of schizophrenia. Method:100 patients were randomly assigned to olanzapine group or aripiprazole group respectively for 8 weeks.The positive and negative symptom scale(PANSS) and clinical global impressions-severity of illness rating scale(CGI-SI) were used to measure the efficacy;the treatment emergent symptom scale(TESS) was used to measure side effects. Results:Marked improvement rate of olanzapine group was 76.0%,and aripiprazole group was 72.0%,the efficacy was similar in two groups(P>0.05);side effects of olanzapine were drowsiness,increase of body weight and blood pressure,which were obviously more frequent than in aripiprazole(P<0.01);the main side effects of aripiprazole were extrapyramidal side effects and insomnia or excitement,which were more frequent than those in olanzapine group(P<0.01). Conclusion: Olanzapine had similar effects to aripiprazole in the treatment of schizophrenia.They have high safety.