| 血管紧张素转换酶(ACE)基因多态性与2型糖尿病并视网膜病变的相关性研究 |
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| 引用本文： | 许岚,邓振霞,何戎华,唐建英.血管紧张素转换酶(ACE)基因多态性与2型糖尿病并视网膜病变的相关性研究[J].河北医学,2003,9(1):34-35. |
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| 作者姓名： | 许岚 邓振霞 何戎华 唐建英 |
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| 作者单位： | 江苏省无锡市第一人民医院,江苏,无锡,214002 |
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| 摘 要： | 目的：探讨血管紧张素转换酶（ACE）基因多态性与2型糖尿病并视网膜病变（DR）的关系。方法：应用PCR方法检测2型糖尿病患者和健康者ACE基因的缺失／插入多态性。结果：2型糖尿病并DR的DD基因型及D等位基因频率与DR组相比有显著性差异。结论：2型糖尿病患者中DD基因型和D等位基因携带者具有患DR易感性。
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| 关 键 词： | 血管紧张素 ACE 基因多态性 2型糖尿病 视网膜病变 |
| 文章编号： | 1006-6233(2003)01-0034-04 |
A Correlation between angiotensin-converting enzyme(ACE) gene Polymorphism and retinopathy in patients with type 2 diabetes mellitus |
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| XU Lan,DENG Zhen-xia,HE Rong-hua,et al.A Correlation between angiotensin-converting enzyme(ACE) gene Polymorphism and retinopathy in patients with type 2 diabetes mellitus[J].Hebei Medicine,2003,9(1):34-35. |
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| Authors: | XU Lan DENG Zhen-xia HE Rong-hua |
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| Abstract: | Objective: To clarify if angiotensin-converting enzyme(ACE) gene polymorphism attributes to the development of retinopathy in patients with type 2 diabetes mellitus. Methods: ACE genotypes were determined with PCR method in 136 patients with type 2 diabetes mellitus and 64 normal controls. Results: The DD genotype frequency and DD allele freaqueney were significantly higher in retinopathy group than in group without retinopathy(P<0.05). Conclusions: ACE gene polymorphism attributes to development of retinopathy in patients with type 2 diabetes mellitus. |
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| Keywords: | ACE gene polymorphism Type 2 diabetes mellitus Retinopathy |
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