恶性肿瘤患者化疗前后免疫功能状况及胸腺五肽等的调节作用

目的：研究恶性肿瘤患者的免疫功能状态和调节免疫功能的治疗方法。方法：分别用免疫细胞化学法和生化法检测95例恶性肿瘤患者和18名健康人的细胞免疫功能（CD3、CD4、CD8和CD56）和体液免疫功能（C3、C4、IgA、IgM和IgG）;比较不同治疗方法对患者免疫指标的影响。结果：38例初诊和47例化疗后恶性肿瘤患者与18名健康人的细胞免疫功能比较,肿瘤患者的CD3、CD4和CD4/CD8明显低于健康人,CD8（除生物治疗后）和CD56明显高于健康人,但初诊和化疗后患者间差异无统计学意义,P〈0.05。经胸腺五肽（欧宁）治疗后的22例患者,CD3比例略有上升,CD4和CD4/CD8明显上升,CD8明显下降,CD56略有下降。经中药治疗的16例患者,CD4略有上升,CD8比例明显降低,CD4/CD8明显增高。肿瘤患者与健康人比较,IgG明显高于健康人;经胸腺五肽和中药治疗后,体液免疫功能无明显变化。结论：恶性肿瘤患者细胞免疫功能低下,体液免疫功能基本正常;胸腺五肽和中药治疗后均明显改善了患者的细胞免疫功能,但仍达不到健康人水平;两种治疗方法对体液免疫功能影响不大。

Comparison of immune function between before and after chemotherapy of patients with malignant tumors and immune regulatory function of drugs

OBJECTIVE: To investigate the immune function of patients with malignant tumors and study the therapy methods to regulate the immune function. METHODS: The cellular immune (CD3, CD4, CD8, CD56) was tested in 95 malignant patients and 18 normal persons by the immunocytochemistry method and the humoral immunity (C3, C4, IgA, IgM, IgG) by the biochemistry method. The treatment effects on immune was compared between before and after chemotherapy, thymopentin and Chinese herbs. RESULTS: CD3, CD4 and the ratio of CD4/CD8 of 38 malignant patients with preliminary diagnosis and 47 cases after chemotherapy were significanfly lower than those of 18 normal persons as control, and CD8 (except after biotherapy group) and CD56 were much higher than the normal, but there was no significant difference between the two malignant groups. Twenty-two cases among the malignant patients, CD3 increased a little, with CD4 and the ratio of CD4/CD8 increasing obviously after the treatment of thymopentin. However, CD8 decreased evidently and CD56 decreased a little. Of 16 cases after treatment with Chinese herbs, CD4 increased without statistic significance, CD8 decreased obviously,but CD4/CD8 increased obviously. Compared the malignant with the normal, IgG was much higher. No visible change in humoral immune was found in the malignant patients treated with thymopentin and Chinese herbs. CONCLUSIONS: Malignant patients have lower cellular immune and normal humoral immune. The cellular immune of patients is still lower than that of the normal though thymopentin and Chinese herbs can improve it; neither can improve humoral immune.