| 蜂毒、蜂肽抗炎镇痛、变应原性及急性毒性的比较 |
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| 引用本文： | 陈郴永,陈维辛,孙欣.蜂毒、蜂肽抗炎镇痛、变应原性及急性毒性的比较[J].中国中西医结合杂志,1993,13(4):226-227,198. |
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| 作者姓名： | 陈郴永 陈维辛 孙欣 |
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| 作者单位： | 南京生物化学制药研究所，南京生物化学制药研究所，南京生物化学制药研究所 南京 210015，南京 210015，南京 210015 |
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| 摘 要： | 蜂肽是从蜂毒中提取的低分子量多肽成分,对其抗炎镇痛作用与蜂毒进行比较,结果表明蜂肽抑制二甲苯性小鼠耳壳肿胀、角叉菜胶性大鼠足跖肿胀以及对热板法小鼠致痛、酒石酸锑钾致痛的抑制作用均显著大于蜂毒。而蜂肽的变应原性却显著小于蜂毒。提示蜂肽可作为蜂毒的有效成分应用于临床。
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| 关 键 词： | 蜂毒 蜂肽 抗炎剂 变应原性 毒性 |
Comparison of Anti-inflammatory,Analgesic Activities, Anaphylactogenicity and Acute Toxicity between Bee Venom and Its Peptides |
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| Authors: | Chen Chen-yong Chen Wei-xin and Sun Xin |
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| Abstract: | Bee venom 1.0-2.0mg/kg and bee venom peptides 1.0-2.0mg/kg inhibited several inflamma-tory processes, such as ear swelling induced by xylene in mice, edema produced by injecting 1?rrageenin 0.1ml beneath the plantar surface of hind paw in rats and showed a marked analgesicaction induced by the hot plate and potassium antimony tartrate. Bee venom peptides had amarkedly more effective action as compared with bee venom itself. The anaphylactogenicity of beevenom peptides was apparently milder than that of bee venom. The LD_(50) of bee venom ip in miceand bee venom peptides was 7.4mg/kg and 7.9mg/kg respectively. |
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| Keywords: | bee venom bee venom peptides anti-inflammatory agents anaphylactogenicity carrageenin analgesic |
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